File:Model mifepristone bound to progesterone receptor.jpg

Model mifepristone bound to progesterone receptor

Binding of mifepristone (RU486, purple) in the progesterone receptor ligand binding domain (PR LBD, blue/red).

A - ribbon view of the PR LBD copy in the dimer that binds RU486. The coloring represents B-factor changes compared with the equiconformational LBD copy in the PR norethindrone complex. Changes range from −4 (blue) to +44 (red) Å2 and are predominantly restricted to the loop 785–808 and helix 12. The conformation of helix 12 is agonistic, closely packed against the LBD core.

B - superposition of the two PR LBD copies in the dimer, one containing RU486 (coloring as in panel A) and one containing norethindrone (gray). Important residues and loops are marked.

Links: Mifepristone

Reference

<pubmed>19372222</pubmed>

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