File:Hindlimb Tbx2 model.jpg
Model of Tbx2 function in the posterior hindlimb mesenchyme
During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loop. Following proliferative expansion of ZPA-derived cells, a broadened Tbx2 expression (blue) causes Grem1 repression. Progressive displacement of Grem1-secreting cells from the AER terminates e-m signaling (E11.5, dotted arrows). The diagrams illustrate these dynamic signaling activities. Failure of Grem1 repression in Tbx2-deficient hindlimbs causes prolonged e-m signaling.
|Human TBX Family|
Farin HF, Lüdtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM & Kispert A. (2013). Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet. , 9, e1003467. PMID: 23633963 DOI.
© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 7. doi:10.1371/journal.pgen.1003467.g007 Original figure cropped, adjusted in size and labelling.
Cite this page: Hill, M.A. (2019, April 19) Embryology Hindlimb Tbx2 model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Hindlimb_Tbx2_model.jpg
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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|current||10:48, 7 December 2014||1,000 × 607 (84 KB)||Z8600021||==Model of Tbx2 function in the posterior hindlimb mesenchyme== (A) During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loo...|
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