File:Hindlimb Tbx2 model.jpg
Model of Tbx2 function in the posterior hindlimb mesenchyme
During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loop. Following proliferative expansion of ZPA-derived cells, a broadened Tbx2 expression (blue) causes Grem1 repression. Progressive displacement of Grem1-secreting cells from the AER terminates e-m signaling (E11.5, dotted arrows). The diagrams illustrate these dynamic signaling activities. Failure of Grem1 repression in Tbx2-deficient hindlimbs causes prolonged e-m signaling.
|Human TBX Family|
<pubmed>23633963</pubmed>| PLoS Genet.
© 2013 Farin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 7. doi:10.1371/journal.pgen.1003467.g007 Original figure cropped, adjusted in size and labelling.
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|current||11:48, 7 December 2014||1,000 × 607 (84 KB)||Z8600021||==Model of Tbx2 function in the posterior hindlimb mesenchyme== (A) During normal limb bud outgrowth (E10.5) the expression domains of Shh (red), Grem1 (yellow) and Fgf4/9/17 (green) are in close proximity allowing propagation of the e-m signaling loo...|
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