User:Z3415716: Difference between revisions
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==Assessment 1== | |||
== [[Effect of Vitamin D status on clinical pregnancy rates following in vitro fertilisation]] == | |||
[http://www.ncbi.nlm.nih.gov/pubmed/25077107 Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization.] | |||
The study undertaken by Garbedian et al. attempted to investigate whether vitamin D (25-hydroxy-vitamin D) serum level of in vitro patients could predict the successfulness of in vitro fertilisation (IVF). 173 patients participated, having met the criteria of age (18-41 years), follicle-stimulating hormone level (≤12IU/L at day 3 of the menstrual cycle), and consent. | |||
Serum samples were collected from the participating women, prior to oocyte retrieval, and were analysed, dividing the patients into two groups, sufficient (≥75 nmol/L) or insufficient (<75 nmol/L), based on their serum vitamin D levels. Regardless of this division, the IVF procedures were undertaken as per standard protocol. | |||
This article focused on two main outcomes, embryo implantation, and clinical pregnancy. Implantation was described as the establishment of a gestational sac upon ultrasonography screening. Whereas clinical pregnancy assessed via ultrasound, was determined by the visibility of an intrauterine sac. The results were collated, analysed, and compared between the groups in order to discover a relationship, if any, between serum vitamin D levels and both implantation and clinical pregnancy rates. | |||
Garbedian and colleagues found significant differences between the groups’ rate of embryo transfer and clinical pregnancy, however this is not the case in implantation rate. In consistency with the IVF protocols, embryo transfer was to take place on day 5, if at least 5-6 acceptable embryos were developed by day 3 of fertilisation. It was discovered that women with a sufficient level of serum vitamin D were more likely to achieve this step by day 5 than women with low serum vitamin D. Moreover, a higher clinical pregnancy rate was observed within the same group of women. An increased value of embryo implantation rate was noted, however results were statistically insignificant. | |||
With acknowledgement of the study’s limitations, Garbedian et al. concluded that women sufficient in vitamin D serum levels were more likely to achieve clinical pregnancy following IVF, with serum levels of the vitamin acting as an independent predictor. | |||
Revision as of 21:43, 12 August 2014
Lab Attendance
Lab 1 --Z3415716 (talk) 12:52, 6 August 2014 (EST)
http://www.ncbi.nlm.nih.gov/pubmed
<pubmed>25084016</pubmed>
Assessment 1
Effect of Vitamin D status on clinical pregnancy rates following in vitro fertilisation
Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization.
The study undertaken by Garbedian et al. attempted to investigate whether vitamin D (25-hydroxy-vitamin D) serum level of in vitro patients could predict the successfulness of in vitro fertilisation (IVF). 173 patients participated, having met the criteria of age (18-41 years), follicle-stimulating hormone level (≤12IU/L at day 3 of the menstrual cycle), and consent. Serum samples were collected from the participating women, prior to oocyte retrieval, and were analysed, dividing the patients into two groups, sufficient (≥75 nmol/L) or insufficient (<75 nmol/L), based on their serum vitamin D levels. Regardless of this division, the IVF procedures were undertaken as per standard protocol.
This article focused on two main outcomes, embryo implantation, and clinical pregnancy. Implantation was described as the establishment of a gestational sac upon ultrasonography screening. Whereas clinical pregnancy assessed via ultrasound, was determined by the visibility of an intrauterine sac. The results were collated, analysed, and compared between the groups in order to discover a relationship, if any, between serum vitamin D levels and both implantation and clinical pregnancy rates.
Garbedian and colleagues found significant differences between the groups’ rate of embryo transfer and clinical pregnancy, however this is not the case in implantation rate. In consistency with the IVF protocols, embryo transfer was to take place on day 5, if at least 5-6 acceptable embryos were developed by day 3 of fertilisation. It was discovered that women with a sufficient level of serum vitamin D were more likely to achieve this step by day 5 than women with low serum vitamin D. Moreover, a higher clinical pregnancy rate was observed within the same group of women. An increased value of embryo implantation rate was noted, however results were statistically insignificant.
With acknowledgement of the study’s limitations, Garbedian et al. concluded that women sufficient in vitamin D serum levels were more likely to achieve clinical pregnancy following IVF, with serum levels of the vitamin acting as an independent predictor.
