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Lab Attendance

Lab 1

--Z3332863 11:47, 25 July 2012 (EST)

Origin of Nobel Prize & Discoverer

In 2010, Robert G. Edwards won the Nobel Prize for developing In vitro Fertilisation. IVF originated in 1950s when Edwards began fertilizing human eggs in cell culture dishes as a way of treating infertility. In 1978, Edward's IVF technology gave the world's first IVF baby. Over the next few years, Edwards and his team fine-tuned the technique of IVF.

[1]

Research paper on fertilisation:

What does this paper tell us about fertilisation?

This article looks at the rise of aneuploidies in IVF embryos in older women. To do this Handyside et al, used 'microarray genomic hybridisation' technology to study the chromosome copy number of the zygote, the 1st and 2nd polar bodies in aged women receiving IVF treatment. Handyside et al, found that unlike natural fertilization, most of the aneuploidies of IVF embryos arose from the 2nd meiotic division, not the first. They also found the aneuploidies were not due to non-disjunction (chromatids not separating in anaphase. anueploidies in IVF embryos were due to premature predivsion of the chromosomes.

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 '''Origin of Nobel Prize & Discoverer'''
-In 2010,Robert G. Edwards won the Nobel Prize for developing In vitro Fertilisation. IVF originated in 1950s when Edwards began fertilizing human eggs in cell culture dishes as a way of treating infertility. In 1978, Edward's IVF technology gave the world's first IVF baby. Over the next few years, Edwards and his team fine-tuned the technique of IVF.
+In 2010, Robert G. Edwards won the Nobel Prize for developing In vitro Fertilisation. IVF originated in 1950s when Edwards began fertilizing human eggs in cell culture dishes as a way of treating infertility. In 1978, Edward's IVF technology gave the world's first IVF baby. Over the next few years, Edwards and his team fine-tuned the technique of IVF.
 [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2010/press.html/]
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 '''Research paper on fertilisation:'''
-<pubmed>11853790</pubmed>
+<pubmed>22317970</pubmed>
 '''What does this paper tell us about fertilisation?'''
-This paper, by Strömberg et al, looks at the risk of neurological problems in children born by In Vitro fertilization (IVF).  This study found the children born after IVF had an increased risk of Cerebral palsy. The number of these children having developmental delay was 4 times higher than children born from normal fertilization. IVF children that were born prematurely and have Low birth weights needed assistance from childhood disability centres more frequently than those full term children, born with normal weights. Compared with singletons (single birth children), IVF twins have higher risk of needing habilitation from these disability centres. This study also found no association between maternal age and risk of neurological disorders. The conclusions that can be drawn from this study are:
+This article looks at the rise of aneuploidies in IVF embryos in older women. To do this Handyside et al, used 'microarray genomic hybridisation' technology to study the chromosome copy number of the zygote, the 1st and 2nd polar bodies in aged women receiving IVF treatment. Handyside et al, found that unlike natural fertilization, most of the aneuploidies of IVF embryos arose from the 2nd meiotic division, not the first. They also found the aneuploidies were not due to non-disjunction (chromatids not separating in anaphase. anueploidies in IVF embryos were due to premature predivsion of the chromosomes.
-* IVF children have higher chance of cerebral palsy amongst other neurological/developmental disorders
-* IVF children are often born prematurely as twins (multiple births)with low birthweights.
-* Thus, increased neurological disorders may be due to multiple births and implanting one embryo during IVF may reduce that chance of neurological disorders in IVF children.
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