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'''What does this paper tell us about fertilisation?''' | '''What does this paper tell us about fertilisation?''' | ||
This article looks at the rise of aneuploidies in IVF embryos in older women. To do this Handyside et al, used 'microarray genomic hybridisation' technology to study the chromosome copy number of the zygote, the 1st and 2nd polar bodies in aged women receiving IVF treatment. Handyside et al, found that unlike natural fertilization, most of the aneuploidies of IVF embryos arose from the 2nd meiotic division, not the first. They also found the aneuploidies were not due to non-disjunction | This article looks at the rise of aneuploidies in IVF embryos in older women. To do this Handyside et al, used 'microarray comparative genomic hybridisation' technology to study the chromosome copy number of the zygote, the 1st and 2nd polar bodies in aged women receiving IVF treatment. Handyside et al, found that unlike natural fertilization, most of the aneuploidies of IVF embryos arose from the 2nd meiotic division, not the first. They also found the IVF aneuploidies that did occur in the first meiotic division, were not due to non-disjunction. Instead, these Aneuploidies were due to premature predivision of the chromatids. In aged zygotes, often multiple aneuploidies were found. | ||
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Revision as of 13:55, 31 July 2012
Lab Attendance
Lab 1
--Z3332863 11:47, 25 July 2012 (EST)
Origin of Nobel Prize & Discoverer
In 2010, Robert G. Edwards won the Nobel Prize for developing In vitro Fertilisation. IVF originated in 1950s when Edwards began fertilizing human eggs in cell culture dishes as a way of treating infertility. In 1978, Edward's IVF technology gave the world's first IVF baby. Over the next few years, Edwards and his team fine-tuned the technique of IVF.
Research paper on fertilisation:
<pubmed>22317970</pubmed>
What does this paper tell us about fertilisation?
This article looks at the rise of aneuploidies in IVF embryos in older women. To do this Handyside et al, used 'microarray comparative genomic hybridisation' technology to study the chromosome copy number of the zygote, the 1st and 2nd polar bodies in aged women receiving IVF treatment. Handyside et al, found that unlike natural fertilization, most of the aneuploidies of IVF embryos arose from the 2nd meiotic division, not the first. They also found the IVF aneuploidies that did occur in the first meiotic division, were not due to non-disjunction. Instead, these Aneuploidies were due to premature predivision of the chromatids. In aged zygotes, often multiple aneuploidies were found.
