User:Z3330313
Lab sign in
--z3330313 11:14, 2 August 2011 (EST)
--z3330313 12:52, 4 August 2011 (EST)
--z3330313 11:39, 11 August 2011 (EST)
--z3330313 12:45, 18 August 2011 (EST)
--z3330313 11:35, 1 September 2011 (EST)
--z3330313 11:42, 15 September 2011 (EST)
LAB1
1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.'
In Vitro Fertilisation is an ART (Assisted Reproduction technology) technique, used by infertile people. It is a process whereby the egg is fertilised by the sperm outside the body. The first successful IVF baby named Louise Brown was born in1978, the procedure was carried out by Patrick Steptoe and Robert Edwards. And in 2010 the Nobel Prize was awarded to Robert Edwards for the development of in vitro fertilisation.
2. Identify a recent paper on fertilisation and describe its key findings.'
"Not all sperm are equal: functional mitochondria characterize a subpopulation of human sperm with better fertilization potential." <http://www.ncbi.nlm.nih.gov/pubmed/21448461>
This paper proves that not all sperm carry the potential to fertilise an egg. It found that mitochondrial activity plays a major role in the functionality of the sperm. They found that the level of mitochondrial function mirrored sperm quality. In conclusion, whatever the true biological role of sperm mitochondria in fertilization, mitochondrial activity is a clear hallmark of human sperm functionality.
3. Identify 2 congenital anomalies.
-Down syndrome -Cystic fibrosis
--[--z3330313 17:31, 8 August 2011 (EST)] 17:30, 8 August 2011 (EST)] 12:52, 4 August 2011 (EST)
LAB2
Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilization.
The oocyte is surrounded by a glycoprotein membrane called the zone pellucida. It is the barrier that the spermatozoa has to push through to reach the oocyte for fertilisation. The zone pellucida protein 3 is the sperm receptor that the spermatozoa binds to as an pathway to enter the cell. After fertilisation, a cortical reaction occurs where it modifies the ZP3 protein to an inactive form. Thus preventing more than one sperm from fertilising the egg.
--z3330313 15:57, 10 August 2011 (EST)
--z3330313 11:39, 11 August 2011 (EST)
Lab3 Picture
Lab 3 Online Assessment
1. What is the maternal dietary requirement for late neural development?
Folic acid or otherwise known as B vitamin (B9) is helps the neural tube to develop. Without folate the neural tube may not close properly. Thus the baby can develop spina bifida. Vitamin's B6 and B12, the minerals Iron and Magnesium, and all the other major and trace minerals and other nutrients which are involved in normal cell division and replication. Including the amino acids, which are the structural building blocks for new tissue.
2. Upload a picture relating to you group project.
--z3330313 09:37, 18 August 2011 (EST)
--z3330313 12:45, 18 August 2011 (EST) (lab sign in)
LAB4
1. The allantois, identified in the placental cord, is continuous with what anatomical structure?
Bladder
2. Identify the 3 vascular shunts, and their location, in the embryonic circulation.
-Foramen ovale located between atrias and allows direct blood flow between the atria of the embryo without blockage
-Ductus arteriosus located between the pulmonary artery and the ascending aorta.
-Ductus venosus located between the inferior vena cava and the umbilical vein
3. Identify the Group project sub-section that you will be researching.
-Introduction
-History
-Epidemiology
LAB5
1.Which side (L/R) is most common for diaphragmatic hernia and why?
The left side is the most common location for diaphragmatic hernias because it fuses after the right hand side. The failure of the pleuroperitoneal foramen to fuse is the hernia.
--z3330313 02:34, 1 September 2011 (EST)
LAB6
1. What week of development do the palatal shelves fuse?
Week 9
2. What early animal model helped elucidate the neural crest origin and migration of neural crest cells?
Chicken model
3. What abnormality results from neural crest not migrating into the cardiac outflow tract?
Tetralogy of Fallot
LAB7
1. Are satellite cells (a) necessary for muscle hypertrophy and (b) generally involved in hypertrophy?
Satellite cells are not necessary for muscle hypertrophy, however they are involved in the process of development of new muscle fibres.
2. Why does chronic low frequency stimulation cause a fast to slow fibre type shift?
Trisomy 21
-Introduction: Does cover details of the disorder briefly however the format did not flow because for some of the information written it looked as though it belonged to the glossary section of the page. But there was a good use of external links
-Some recent findings: Regarding the flow of the page the next sub heading did not fit. It would be more appealing if the "some recent findings" heading were to be loacted near the end of the page. However, the information was written very well and easy to read/condensed.
-Trisomy 21 (Down Syndrome) Karyotypes : The use of images is to be congratulated, it is a helpful visual aid. However, the use of good image was not taken advantage of in written form. The information written was limited and too brief, the writer relied on the image too much.
-Associated Congenital Abnormalities: This section had a list of the abnormalities however that was just it. There was no explanation of what type of disorder it is or any description what so ever. This section is somewhat of an important sub heading as it deals with abnormal changes to the embryo or fetus during development but the writer only left a brief note which only shows laziness.
-Heart Defect: Very good use of statistics and external links to help the reader understand the information laid out. Most words were hyperlinked to the glossary section, maybe instead of doing that the writer could just incorpate the information into the main text because it is not just one word but a few thus it would be easier to read it in one go also these words are bulletpointed anyways.
-Limb Defects: Good use of external links again and a nice image but why not conbine the previous subheading into one heading as, "DEFECTS" because they were both short pieces of information and they both relate to the same topic so it would thus look more appealing and less spaced.
-It would be a suggestion to have a subheading as "epidemiology" so not only information on prevalence will be covered but also statistics on rate of incidence etc.. and why it is occurring at that rate. Furthermore, if Australian statistics were to be used than that would be fantastic as it would be more relevant to us.
-The reference list was good. It was categorised into the different types of sources used. A good job!
--z3330313 00:22, 22 September 2011 (EST)
