User:Z3308968: Difference between revisions
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1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation. | 1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation. | ||
2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page) | |||
Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) acts as a sperm receptor. is a protein that in humans is encoded by the ZP3 gene.[2][3] ZP3 is the receptor in the zona pellucida which binds sperm at the beginning of fertilization. | |||
ZP3 surrounds the oocyte, and the sperm binds to it as a way to enter the cell. Once a sperm has entered the oocyte, mechanisms to prevent polyspermy are put in place. The IP3 pathway is activated and in increase in intraceellular calcium results in alteration of ZP3 to prevent any more sperm entering the oocyte. | |||
2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page) | |||
===Lab 3 Questions=== | ===Lab 3 Questions=== | ||
Revision as of 21:31, 8 August 2011
Group 11
Attendance
Lab 1. not enrolled yet
Lab 2. --Tahmina Lata 11:01, 4 August 2011 (EST)
Lab 3.
Lab 4.
Lab 5.
Lab 6.
Lab 7.
Lab 8.
Lab 9.
Lab 10
Lab 11.
Lab 12.
Lab Questions
Lab 1 Questions
1. Identify the origin of In Vitro Fertilization and the 2010 nobel prize winner associated with this technique.
In the year 1950 Robert G. Edwards started working on In Vitro Fertilization and on 25 July, 1978, his project succeeded in producing the world's first "test tube baby." The Nobel Prize in Physiology or Medicine 2010 was consequently awarded to Robert G. Edwards for the development of in vitro fertilization. [1]
2. Identify a recent paper on fertilisation and describe its key findings.
A study of fertility after age 45 was attempted with the aim of reversing the age-related decline in oocyte quality through micro-manipulation of the nucleus and cytoplasm. However it has yielded disappointing results coupled with fears of ethical concerns. [2]
3. Identify 2 congenital anomalies.
Atrial septal defect (ASD)is a form of congenital heart defect that results in the mixing of arterial and venous blood.
Spina bifida is a congenital disorder results from the incomplete closing of the embryonic neural tube.
Lab 2 Questions
1. Identify the ZP protein that spermatozoa binds and how is this changed (altered) after fertilisation.
Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) acts as a sperm receptor. is a protein that in humans is encoded by the ZP3 gene.[2][3] ZP3 is the receptor in the zona pellucida which binds sperm at the beginning of fertilization.
ZP3 surrounds the oocyte, and the sperm binds to it as a way to enter the cell. Once a sperm has entered the oocyte, mechanisms to prevent polyspermy are put in place. The IP3 pathway is activated and in increase in intraceellular calcium results in alteration of ZP3 to prevent any more sperm entering the oocyte.
2. Identify a review and a research article related to your group topic. (Paste on both group discussion page with signature and on your own page)
Lab 3 Questions
Lab 4 Questions
Lab 5 Questions
Lab 6 Questions
References
- ↑ Our founder editor, Robert G. Edwards, wins the Nobel Prize for Medicine. Reprod Biomed Online. 2010 Dec;21(7):829. PubMed PMID: 21112539
- ↑ Forman EJ, Treff NR, Scott RT Jr. Fertility after age 45: From natural conception to Assisted Reproductive Technology and beyond. Maturitas. 2011 Aug 1. [Epub ahead of print] PubMed PMID: 21813248
