Template:Leptin table
From Embryology
| Leptin effects on female reproduction | |||
|---|---|---|---|
| Target Tissue | Biological Process | Biological Function | Mechanism |
| Hypothalamus | GnRH secretion | Regulation of LH and FSH secretion | Indirectly via kisspeptin |
| Pituitary | Estrous cycles and ovulation | FSH and LH release; LH plasticity and cyclicity | |
| Ovary | Ovarian steroidogenesis | Estrogen production | P450 aromatase; P450-17α hydroxylase |
| Ovary | Folliculogenesis | Low leptin promotes follicle development | Promotes the transition of primordial to primary follicles |
| Embryo | Embryogenesis | Biophysical effect on embryo growth and quality | Stimulates proliferation |
| Uterus | Angiogenesis | Stimulates metalloproteinase activity | Inhibits terminal differentiation of committed giant cells |
| Table modified from:<pubmed>24908087</pubmed> | |||
