Template:Anderson2016 collapsetable2
From Embryology
| Table 2. Summary of Timing (Post Fertilization) of Cardiac Susceptibility to a Drug-Induced Malformation | ||
|---|---|---|
| Lesion | Start of Susceptibility to Malformation |
End of Susceptibility to Malformation |
| Interatrial communications | ||
| Oval fossa defect | 6 weeks (E13.5) | Term |
| Sinus venosus defect | 8 weeks | 12 weeks |
| Coronary sinus defect | 8 weeks | Term |
| Vestibular defect | 7 weeks | 8 weeks |
| Ventricular Septal Defect | ||
| Muscular | 8 weeks | Difficult to predict |
| Perimembranous | 6 weeks | 8 weeks |
| Doubly committed | 7 weeks | 8 weeks |
| Atrioventricular Septal Defect | ||
| Ostium primum | 5 weeks | 6 weeks |
| “Complete” | 5 weeks | 6 weeks |
| Aortic coarctation | ||
| With VSD | 5 weeks | 8 weeks |
| With intact ventricular septum | 8 weeks | Term |
| Double Outlet Right Ventricle | 6 weeks | 8 weeks |
| Transposition of Great Arteries | 6 weeks | 8 weeks |
| Ebstein’s malformation | 6 weeks | 8 weeks |
| Hypoplastic left heart syndrome | ||
| With mitral atresia | 5 weeks | 8 weeks |
| With mitral stenosis | 8 weeks | Term |
| Pulmonary atresia | ||
| With VSD | 6 weeks | 8 weeks |
| With intact ventricular septum | 8 weeks | Term |
| Other | ||
| Functionally single ventricle | 5 weeks | 6 weeks |
| Tetralogy of Fallot | 7 weeks | 8 weeks |
| Totally anomalous pulmonary venous return | 8 weeks | 12 weeks |
| Tricuspid atresia | 5 weeks | 6 weeks |
| Common arterial trunk | 5 weeks | 7 weeks |
| Bicuspid aortic valve | 6 weeks | Term |
|
Notes: For approximate clinical Gestational Age GA add 2 weeks; number in brackets is mouse equivalent. Reference: Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016) | ||
