Talk:Book - Sex and internal secretions (1961) 4

I. Introduction 241

II. The Hypophyseal CioNADOxROPHiNS. . . 241

A. Follicle stiiniilatiiig Hormone 242

1. Ch(Mnic;il f(.;i lures 242

2. Physiologic criccts in females 243

3. Physiologic etfects in males 244

4. FSH in relation to compensatory

gonadal responses 244

5. Assay 245

B. Luteinizing Hormone (Interstitial Cell-stimulating Hormone) 245

1. Chemical features 245

2. Pln'siologic effects in females 246

3. Physiologic action in males 246

4. An extragonadal activity 247

5. FSH and LH in relation to estrogen secretion 247

6. FSH and LH, interactions 247

7. Assay 248

C. Luteotrophin (Prolactin) 249

1. Chemical features 249

2. Physiology of luteotrophic hormone (prolactin) 249

3. Detection and assay of prolactin activity 250

III. Pituitary Gonadotrophic Hormone Content and Related Evidence of Secretory Activity 250

A. Phylogenetic Considerations 251

1. Ascidians 251

2. Fish 252

3. Amphibians 252

4. Reptiles 253

5. Birds 253

6. Mammals 254

7. (Jeneral considerations 255

li. Age, Sex, (Jonadectomy, and Reproductive Rhythms in Relation to Pituitary C.onadotrophins 256

1. Fetal gonadotrophins 256

2. Age and sex 256

3. (Jonadectomy 258 4. Reproductive rhythms 259

C. Effect of Dietary Restrictions on Pituitary Gonadotropliic Potency and Function 261

1. Underfeeding 261

2. Vitamin deficiencies 262

3. Deficiency in intake of protein or of specific amino acids 262

IV. Gonadal-hypophyseal Interrelationships 263

A. Immaturity 263

B. Puberty and Maturity 264

C. Effects of Estrogens on Follicle-stimulating Hormone Secretion 265

D. Effect of Estrogen on Luteinizing Hormone and Luteotrophin Hormone Secretion 267

E. Differential Effects of Gonadal Steroids on Follicle-stimulating Hormone and Luteinizing Hormone Secretion 268

F. Effects of Androgens on Pituitary Gonadotrophins 268

G. either Steroids and Oxidation Products 271

H. Effect of Progesterone on Pituitary Gonadotrophic Functions 271

I. Neurohypophyseal Influences on Gonadotrophin Secretion 272

V. Anatomic Features Important to Modern Concepts of Pituitary Gonadrotrophic Function 272

A. Innervation of the Hypophysis . . 273

B. The Median Eminence and the Infundibular Stem 274

C. The Hypophyseal Portal Circulatory System 275

i). The Hypothalamic and Hypophyseal Mediated Sexual Functions 276

1. Environmental stimuli 276

2. Electrical stimulation of the hypothalamus 278

3. Lesions in the hypothalamus 279

4. Transection of the hypophyseal stalk 280

VI. References 284