Talk:Book - Sex and internal secretions (1961) 2
I. The Hormone Theory of Sex Differentiation 76
II. Methods of Experimental Analysis 78
A. Grafting of Gonads or Gonad Tis sues in Bird Embryos 78
B. Grafting Experiments in Amphib ian Embrj'os 79
C. Use of Pure Hormones as Sex Dif ferentiating Agents 82
D. Sex Differentiation in the Absence
of Hormones 82
III. The Bisexual Organization of the
IiIarly Embryo as the Basis of Sex Reversal 83
IV. Experimental Reversal of Sex Dif ferentiation IN the Gonads 83
A. Bisexual Organization of the Gonad
and the Physiologic Mechanism
of Sex Differentiation 83
B. Sex Reversal in Amphibian Gonads 86
1. Constitutional differences and
the character of the reversal process 80
2. Parabiosis and grafting of the
gonad or the gonad primordium 87
3. Administration of steroid hor
mones 91
C. Sex Rkv'ersal in Avian (Ionads. 95
1. Organization of avian gonads. . . 95
2. Effects of administering pure
hormones 9(i
3. Effects of grafting gonads into
the coelomic cavity 99
4. Sex reversal in vitro 100
D. The Problem of Sex Reversal in
Mammalian Gonads 100
1. Bisexual potentialities in the embryonic gonads of mammals 100
2. Bisexual potentiality in the em bryonic ovary of the rat 103
3. Experimental transformation
of the testis in the opossum. . . 105 V. The Role of Hormones in the Development OF the Accessory Sex Structures 110
A. Differentiation of the Embryonic
Gonaducts Ill
1. The Miillerian ducts 112
2. The male duct system 120
B. Derivatives of the Cloaca and
Urinogenital Sinus 121
C. External Genital Structures 127
D. Differentiation of Other Types of
Sex Character 129
VI. The Pituitary and the Differentiation OF Sex 132
VII. Group Differences in the Relations OF Hormones to Sex 134
VIII. The Organization of the Sex Primordium AND Its Role in the Differentiation OF Sex 137
A. Constitution and the Morphologic
Representation of Sex Primordia 137
B. Constitutional Factors and Physi ologic Differences in the Organization of Sex Primordia 138
C. Influence of Sex Genotype on the
Reactions of Sex Primordia 139
IX. The Time F'.^ctor in the Responses
OF Sex Primordia: Receptivity
and "Critical Periods" 140
X. Specificity of Hormone Action and the Significance of P.\radoxical
Effects 141
XI. Time of Origin and the Source of
(ioNAD HoR.MONES 143
XII. A Comparison of the Effects of EmBRYt)Nic and Adult Hormones in Skx Differentiation 145
.\1I1. IvMBRYONic Hormones and Inductor
Substances 148
XIV. References 151