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  • 16:19, 27 July 2009 MarkHill talk contribs uploaded File:Trisomy21male.jpg (Down syndrome or trisomy 21 is caused by nondisjunction of chromosome 21 in a parent who is chromosomally normal and is one of the most common chromosomal abnormalities in liveborn children. The frequency of trisomy 21 in the population is approximately 1)