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Date Name Thumbnail Size Description Versions
20:34, 4 October 2011 Role of FXN Gene.jpg (file) 51 KB A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frata 1
20:28, 4 October 2011 Role of FXN Gene in Friedriech Ataxia.jpg (file) 51 KB A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frata 2
20:48, 4 October 2011 Effect of Frataxin Levels.jpg (file) 84 KB ==Frataxin Levels in Mitochondria== Image is a diagram of cellular function of decrease levels of frataxin within the Mitochondrial Matrix which causes a cascade of effects leading to the main causes of symptoms described of Friedreich Ataxia. Inspirati 1
21:44, 7 October 2011 Frataxin Protein.png (file) 211 KB Frataxin is the protein which produced by the FXN gene. Decreased levels of Frataxin can lead mitochondrial distress and cascade of secondary reaction, this images conveys a 3D visual of the protein of the genetic origins of Friedreich Ataxia =References 1
00:41, 16 August 2011 Gene expression responses of Friedreich's ataxia.jpg (file) 342 KB '''Gene expression responses of Friedreich's ataxia''' ---- ==Analogous gene expression responses in blood from children and adults with FRDA.== ---- (A) A common gene signature is representative of a genotoxic stress response found by Gene Set Analysis. 1