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Peyer's patch

The following papers and reviews refer to the immune function of the Peyer's patch.

The light and dark sides of intestinal intraepithelial lymphocytes

Nat Rev Immunol. 2011 Jun 17;11(7):445-56. doi: 10.1038/nri3007.

Cheroutre H1, Lambolez F, Mucida D.

Abstract

The intraepithelial lymphocytes (IELs) that reside within the epithelium of the intestine form one of the main branches of the immune system. As IELs are located at this critical interface between the core of the body and the outside environment, they must balance protective immunity with an ability to safeguard the integrity of the epithelial barrier: failure to do so would compromise homeostasis of the organism. In this Review, we address how the unique development and functions of intestinal IELs allow them to achieve this balance.

PMID 21681197

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140792/

Peyer's patch dendritic cells as regulators of mucosal adaptive immunity

Cell Mol Life Sci. 2005 Jun;62(12):1333-8.

Sato A1, Iwasaki A.

Abstract

The mucosal immune system maintains a delicate balance between providing robust defense against infectious pathogens and, at the same time, regulating responses toward innocuous environmental and food antigens and commensal microbes. The Peyer's patch (PP) has been studied in detail as a major inductive site for mucosal immunity within the small intestine. While the mechanisms responsible for the induction of mucosal immunity versus tolerance are not yet fully understood, recent studies have highlighted mucosal dendritic cells (DCs) as regulators of the immune responses to orally administered antigens. Here we discuss recent studies that describe the role of PP DCs in immune induction and speculate on the mechanism by which the resident DCs regulate T cell and immunoglobulin A (IgA) responses in the gastrointestinal mucosa.

PMID 15971108

Anatomical basis of tolerance and immunity to intestinal antigens

Nat Rev Immunol. 2003 Apr;3(4):331-41.

Mowat AM1.

Abstract

The intestinal immune system has to discriminate between harmful and beneficial antigens. Although strong protective immunity is essential to prevent invasion by pathogens, equivalent responses against dietary proteins or commensal bacteria can lead to chronic disease. These responses are normally prevented by a complex interplay of regulatory mechanisms. This article reviews the unique aspects of the local microenvironment of the intestinal immune system and discuss how these promote the development of regulatory responses that ensure the maintenance of homeostasis in the gut.

PMID 12669023

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