File talk:Maternal age trisomy 21 study table.png

Maternal Fetus rate at the time of amniocentesis Live births rate at the time of delivery age This Hook Ferguson- Yaegashi Snijders Park Kim Hecht and Bray Huether Sheu Morris Metkeni study 1983 Smith 1984 1998 1999 [1]a 2010 2013 Hook 1996 1998 1998 1998 2002 2005

34 2.67 3.10 N/A N/A 2.86 N/A N/A 2.27 2.40 2.39 3.17 2.20 1.50 35 2.93 4.00 3.80 2.62 3.57 3.68 7.78 2.81 2.97 2.94 4.00 2.84 2.30 36 3.90 5.20 4.90 3.37 4.55 4.59 9.15 3.56 3.72 3.68 4.83 3.76 2.60 37 5.58 6.70 6.30 4.31 5.85 5.71 10.77 4.60 4.73 4.68 5.46 5.03 3.90 38 7.98 8.70 8.10 5.50 7.63 7.09 12.67 6.03 6.06 6.03 5.71 6.76 4.60 39 11.09 11.20 10.40 7.03 10.00 8.85 14.91 8.00 7.82 7.88 6.02 9.01 6.90 40 14.91 14.50 13.30 8.98 13.16 10.99 17.54 10.68 10.15 10.46 7.30 11.77 9.20 41 19.44 18.70 17.10 11.47 17.54 13.70 20.64 14.29 13.24 14.08 8.93 14.93 13.70 42 24.69 24.10 21.80 14.66 23.26 17.24 24.29 19.06 17.31 19.22 9.43 18.52 14.70 43 30.65 31.10 27.90 18.73 31.25 21.28 28.58 25.21 22.67 26.58 N/A 22.22 23.20 44 37.32 40.10 35.60 23.93 41.67 26.32 33.63 32.86 29.70 37.18 N/A 25.64 26.20 45 44.70 51.80 45.30 30.57 55.56 33.33 39.57 41.93 38.89 52.55 N/A 28.57 27.40 46 52.80 66.8 57.5 N/A N/A N/A 46.57 52.03 50.83 52.55 N/A 32.26 33.3 47 61.61 86.2 23.3 N/A N/A N/A 54.79 62.32 66.26 52.55 N/A 34.48 44.7 48 71.14 111.2 23.3 N/A N/A N/A N/A 71.53 86.00 52.55 N/A 37.04 51.9 Sample 17,819 N/A 52,965 5,484 57,614 2,032 5,055 1,615,142 N/A N/A 7,232,689 6,008,450 4,139,205 size Study Thailand Mixed Europe Japan US Korea Korea Mixed Mixed South- Taiwan England & Hungary location west Ohio Wales and Atlanta (White US)

N/A: not available. aAt the gestational age of 16 weeks. “Age at the time of delivery.

doi:10.1371/journa|.pone.O165859.t002