File talk:Model Hox10 kidney development.jpg
From Embryology
Transcription factors and signals necessary for ureteric bud induction.[1]
- Hox11, Pax2, Eya1, Wt1, and Sall1 - promote Gdnf expression in the condensed metanephric mesenchyme prior to ureteric bud induction.
- Foxc1, Foxc2, Robo, and Slit - limit the anteroposterior (AP) expression boundary of Gdnf in the mesenchyme.
- Gdnf - recognized by cRet and Gfrα1 receptors on the ureteric bud, which forms from the Wolffian duct.
- ↑ PMID 21553325
