File:Signalling factors in lung branching cartoon.png

Signalling factors in lung branching cartoon

A graphical summary of the modelled interactions of the signaling factors in lung bud during morphogenesis.

GF10 is transcribed at high levels in the distal mesenchyme (grey) and experiments suggest that FGF10 promotes both the proliferation of the endoderm and its outward movement (green arrow). FGF10 stimulates the expression of SHH in the epithelium (red). SHH reversibly binds its receptor Ptc1 which is expressed in the mesenchyme (grey). SHH-Ptc binding results in the repression of FGF10 expression.

Reference

Menshykau D, Kraemer C, Iber D (2012) Branch Mode Selection during Early Lung Development. PLoS Comput Biol 8(2): e1002377. doi:10.1371/journal.pcbi.1002377

http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002377

Copyright Information

© 2012 Menshykau et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

--Mark Hill (talk) 14:50 7 November 2014 (EST) Assessment - Figure relates to project topic contains reference, copyright and student template. reference should have been formatted with pubmed extension. There is no further description to identify when this signalling process occurs (embryonic/fetal). There should also be an explanation of the factors in the figure.

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