File:Role of UBE3A in dendritic spine neuronal synapses.png

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A. Normal mice contain the gene UBE3A which ubiquitinates neuronal proteins Arc and Eph-5, resulting in proteasomal degradation

B. UBE3A deficient mice exhibit abnormal dendritic spine morphology due to the activation of RhoA. This is a direct result of Arc and Eph-5 not being degraded as they have not been tagged by UBE3A.


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Adapted by permission from Macmillan Publishers Ltd: : [Nature] (Scheiffele P, Beg AA: Neuroscience: Angelman syndrome connections. Nature 2010; 468: 907-908.), copyright (2010)


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Cite this page: Hill, M.A. (2024, June 17) Embryology Role of UBE3A in dendritic spine neuronal synapses.png. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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