File:Role of UBE3A in dendritic spine neuronal synapses.png

From Embryology

Original file(725 × 621 pixels, file size: 94 KB, MIME type: image/png)

A. Normal mice contain the gene UBE3A which ubiquitinates neuronal proteins Arc and Eph-5, resulting in proteasomal degradation

B. UBE3A deficient mice exhibit abnormal dendritic spine morphology due to the activation of RhoA. This is a direct result of Arc and Eph-5 not being degraded as they have not been tagged by UBE3A.

Reference

Illustration by z3291643

Adapted by permission from Macmillan Publishers Ltd: : [Nature] (Scheiffele P, Beg AA: Neuroscience: Angelman syndrome connections. Nature 2010; 468: 907-908.), copyright (2010) https://s100.copyright.com/MyAccount/web/jsp/viewprintablelicensefrommyorders.jsp?licenseOID=2011091_1316403095341&email=

<pubmed>21164477</pubmed>

Beginning six months after publication, I (3291643) grant the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode


Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.




Cite this page: Hill, M.A. (2024, June 17) Embryology Role of UBE3A in dendritic spine neuronal synapses.png. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Role_of_UBE3A_in_dendritic_spine_neuronal_synapses.png

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan

GwalagizhiNyangagiDimensionsUserComment
current20:31, 17 September 2011Thumbnail for version as of 20:31, 17 September 2011725 × 621 (94 KB)Z3291643 (talk | contribs)

The following page uses this file: