File:Pathogenesis of Friedreich Ataxia.jpg

From Embryology

Pathogenesis_of_Friedreich_Ataxia.jpg(520 × 380 pixels, file size: 30 KB, MIME type: image/jpeg)

Figure 5

Model of Friedreich's ataxia pathology based on this study. Data presented in this study are consistent with a dysregulation of mitochondrial function, decreased oxidative phosphorylation, increased ROS production, and subsequent mitochondrial and nuclear DNA damage. These factors contribute to decreased signaling and altered DNA transactions, which are likely to result in subsequent loss of protein synthesis and decreased protein degradation, as suggested in the transcription profiling. These alterations may cause tissue damage, altered immune response, and the clinical pathology associated with FRDA.

Reference

<pubmed>20090835</pubmed>| PMC2799513


Copyright This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.


Assessment

+ Relevant figure for group topic. - You have simply used the original legend without interpretation. For example "Model of Friedreich's ataxia pathology based on this study.", the original paper study not your group project.


Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.




Cite this page: Hill, M.A. (2024, June 15) Embryology Pathogenesis of Friedreich Ataxia.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Pathogenesis_of_Friedreich_Ataxia.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current11:25, 16 August 2011Thumbnail for version as of 11:25, 16 August 2011520 × 380 (30 KB)Z3329495 (talk | contribs)Figure 5 Model of Friedreich's ataxia pathology based on this study. Data presented in this study are consistent with a dysregulation of mitochondrial function, decreased oxidative phosphorylation, increased ROS production, and subsequent mitochondrial an
11:23, 16 August 2011Thumbnail for version as of 11:23, 16 August 2011256 × 256 (9 KB)Z3329495 (talk | contribs)Figure 5 Model of Friedreich's ataxia pathology based on this study. Data presented in this study are consistent with a dysregulation of mitochondrial function, decreased oxidative phosphorylation, increased ROS production, and subsequent mitochondrial an

The following 3 pages use this file: