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Summary of canonical Notch signaling

DSL ligands and Notch receptors are multidomain transmembrane containing proteins. Notch-DSL interactions spanning neighboring cells trigger proteolytic cleavage of Notch, generating the Notch intracellular domain (NICD). NICD localizes to the nucleus where it forms a ternary complex with the DNA binding protein CSL and the transcriptional coactivator Mastermind (MAM), to activate transcription from Notch target genes. In the absence of NICD, CSL binds corepressor proteins (CoR) to repress transcription from Notch responsive sites.

Abbreviations: DSL (Delta, Serrate, Lag-2), MNNL (Module at N-terminus of Notch Ligands), NRR (Negative Regulatory Region), LNR (LIN12-Notch Repeats), HD heterodimerization domain), RAM (RBP-J associated molecule), ANK (ankyrin repeats).


Reference

<pubmed>27404588</pubmed>


Copyright

© Yuan et al. (2016). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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