File:Neurpore cell shape changes.png

Cell shape changes in the midline after mid-hindbrain neuropore (MHNP) closure in vivo

a The relationship between the closing of MHNP and the somite stage in ICR strain mouse.

b-f Dorsal views of embryos stained with E-cadherin (Ecad). Non-neural ectodermal cells change their shapes dramatically from bipolar to polygonal after the MHNP closure.

g, h Higher manigification views of embryos (c, e) that were co-stained with Ecad, apoptotic marker active-Caspase 3 (aCasp 3), and nuclear staining (DNA). Dorsal views, left is rostral side.

Scale bars: (b-f) 100 μm in upper panels, and 25 μm in (g, h) middle and (b-f) lower panels

Links: neural | mouse | apoptosis

Reference

Shinotsuka N, Yamaguchi Y, Nakazato K, Matsumoto Y, Mochizuki A & Miura M. (2018). Caspases and matrix metalloproteases facilitate collective behavior of non-neural ectoderm after hindbrain neuropore closure. BMC Dev. Biol. , 18, 17. PMID: 30064364 DOI.

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© The Author(s). 2018

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Fig. 3

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