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A schematic and simplistic representation of the expression of Sox2 and Sox3 during development of the ear. | '''A schematic and simplistic representation of the expression of Sox2 and Sox3 during development of the ear.''' | ||
Before the otic placode becomes distinct, Sox3 is already expressed in a broad area around the location of the future otic placode. Later in it will only be found in the proneural region of the otic placode. It is suggested that a neural fate acquisition occurs prior to otic placode formation. During the early stages of development of the otocyst, Sox2 and Sox3 are found in proliferating cells within the proneural region. Both are expressed when neurons are generated, however, Sox3 switches off and only Sox2 remains during further development of the ear. This suggests that the ongoing expression of Sox2 plays a role in sensory cell development. | Before the otic placode becomes distinct, Sox3 is already expressed in a broad area around the location of the future otic placode. Later in it will only be found in the proneural region of the otic placode. It is suggested that a neural fate acquisition occurs prior to otic placode formation. During the early stages of development of the otocyst, Sox2 and Sox3 are found in proliferating cells within the proneural region. Both are expressed when neurons are generated, however, Sox3 switches off and only Sox2 remains during further development of the ear. This suggests that the ongoing expression of Sox2 plays a role in sensory cell development. | ||
Revision as of 17:00, 7 September 2012
A schematic and simplistic representation of the expression of Sox2 and Sox3 during development of the ear.
Before the otic placode becomes distinct, Sox3 is already expressed in a broad area around the location of the future otic placode. Later in it will only be found in the proneural region of the otic placode. It is suggested that a neural fate acquisition occurs prior to otic placode formation. During the early stages of development of the otocyst, Sox2 and Sox3 are found in proliferating cells within the proneural region. Both are expressed when neurons are generated, however, Sox3 switches off and only Sox2 remains during further development of the ear. This suggests that the ongoing expression of Sox2 plays a role in sensory cell development.
Student image.
Based upon text from <pubmed>19247974</pubmed>
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