File:Neural domain.jpg

A schematic and simplistic representation of the expression of Sox2 and Sox3 during development of the ear

Before the otic placode becomes distinct, Sox3 is already expressed in a broad area around the location of the future otic placode. Later in it will only be found in the proneural region of the otic placode. It is suggested that a neural fate acquisition occurs prior to otic placode formation. During the early stages of development of the otocyst, Sox2 and Sox3 are found in proliferating cells within the proneural region. Both are expressed when neurons are generated, however, Sox3 switches off and only Sox2 remains during further development of the ear. This suggests that the ongoing expression of Sox2 plays a role in sensory cell development.

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Based upon text from Alsina B, Giraldez F & Pujades C. (2009). Patterning and cell fate in ear development. Int. J. Dev. Biol. , 53, 1503-13. PMID: 19247974 DOI.

Cite this page: Hill, M.A. (2024, April 28) Embryology Neural domain.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Neural_domain.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G