HD_patients.jpg (492 × 442 pixels, file size: 52 KB, MIME type: image/jpeg)
Fig 1. Phenotypically identical twins (A) and skull computed tomography showing head of caudate nucleus atrophy (B and C)
Patients were female, 24 years-old when first examined, and phenotypically identical (Fig 1A). The onset of their disease, as reported by relatives, was at 17 and 20 years of age, the initial manifestations being balance and gait impairment with a progressive course. Neurologic examination showed bradykinesia, rigidity with cogwheel phenomenon, choreic movements of trunk and limbs (mild degree), dysarthria, hyperactive tendon reflexes and flexor plantar responses. The patient with earlier onset of the disease was more severely affected. Neurologic examination was repeated approximately six months and one year after the initial examination, and both patients worsened on each successive examination.
LEVY, GILBERTO et al. Juvenile Huntington's disease confirmed by genetic examination in twins. Arq. Neuro-Psiquiatr. [online]. 1999, vol.57, n.3B [cited 2011-10-01], pp. 867-869 . Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000500022&lng=en&nrm=iso>. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X1999000500022.
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Cite this page: Hill, M.A. (2021, January 27) Embryology HD patients.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:HD_patients.jpg
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|current||17:54, 1 October 2011||492 × 442 (52 KB)||Z3290379||Fig 1. Phenotypically identical twins (A) and skull computed tomography showing head of caudate nucleus atrophy (B and C) Patients were female, 24 years-old when first examined, and phenotypically identical (Fig 1A). The onset of their disease, as report|