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Electroencephalography (EEG) | Electroencephalography (EEG) showing Normal and abnormal EEGs in both human and mouse. | ||
A. | |||
: Normal, Segment of routine EEG on a normal 10-yr-old male with no seizures. | |||
: AS-Deletion, Background EEG of a 9.5-yr-old male, large deletion AS case. | |||
: AS-Non-Deletion, Background EEG of a 10-yr-old male with a UBE3A gene loss-of-function mutation. | |||
B. | |||
: Background EEGs from mouse littermates (gabrb3+/+ and gabrb3−/−) recorded simultaneously at 2 months of age. Electrodes were placed over right and left parietal cortex and referenced to an electrode placed in the nasal bone. Bottom two EEG traces are representative examples from a gabrb3−/− mouse before (b.) and after (a.) administration of ethosuximide (400 mg/kg). Ethosuximide effectively abolished interictal spiking and normalized EEG background. | |||
===Reference=== | ===Reference=== | ||
<pubmed>9763493</pubmed> | <pubmed>9763493</pubmed> | ||
For permissions, please see Discussion page | |||
{{Template:2011 Student Image}} | {{Template:2011 Student Image}} |
Revision as of 10:51, 3 October 2011
Electroencephalography (EEG) showing Normal and abnormal EEGs in both human and mouse. A.
- Normal, Segment of routine EEG on a normal 10-yr-old male with no seizures.
- AS-Deletion, Background EEG of a 9.5-yr-old male, large deletion AS case.
- AS-Non-Deletion, Background EEG of a 10-yr-old male with a UBE3A gene loss-of-function mutation.
B.
- Background EEGs from mouse littermates (gabrb3+/+ and gabrb3−/−) recorded simultaneously at 2 months of age. Electrodes were placed over right and left parietal cortex and referenced to an electrode placed in the nasal bone. Bottom two EEG traces are representative examples from a gabrb3−/− mouse before (b.) and after (a.) administration of ethosuximide (400 mg/kg). Ethosuximide effectively abolished interictal spiking and normalized EEG background.
Reference
<pubmed>9763493</pubmed>
For permissions, please see Discussion page
- Note - This image was originally uploaded as part of a student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.
Cite this page: Hill, M.A. (2024, May 1) Embryology Electroencephalography of Angelman Syndrome.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Electroencephalography_of_Angelman_Syndrome.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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