File:Electroencephalography of Angelman Syndrome.jpg

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Electroencephalography of Angelman Syndrome

Electroencephalography (EEG) showing Normal and abnormal EEGs in both human and mouse.


Normal, Segment of routine EEG on a normal 10-yr-old male with no seizures.
AS-Deletion, Background EEG of a 9.5-yr-old male, large deletion AS case.
AS-Non-Deletion, Background EEG of a 10-yr-old male with a UBE3A gene loss-of-function mutation.

The above illustrates that seizures are most severe in AS cases with deletion of the UBE3A gene.


Background EEGs from mouse littermates (gabrb3+/+ and gabrb3−/−) recorded simultaneously at 2 months of age. Electrodes were placed over right and left parietal cortex and referenced to an electrode placed in the nasal bone. Bottom two EEG traces are representative examples from a gabrb3−/− mouse before (b.) and after (a.) administration of ethosuximide (400 mg/kg). Ethosuximide effectively abolished interictal spiking and normalized EEG background.



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+ Relevant to group project topic. + Includes source, copyright information and student disclaimer. + Additional information in figure legend, no peer learning criteria. - The legend requires more introductory information for peer teaching to understand/interpret what is being shown in the Electroencephalograph.

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Cite this page: Hill, M.A. (2024, June 17) Embryology Electroencephalography of Angelman Syndrome.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan

current10:46, 3 October 2011Thumbnail for version as of 10:46, 3 October 2011440 × 207 (33 KB)Z3291643 (talk | contribs)Electroencephalography (EEG) ===Reference=== <pubmed>9763493</pubmed> {{Template:2011 Student Image}}

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