View source for File:Cells of the innate and adaptive immune system present in the uterus at the time of implantation.jpg

==Cells of the innate and adaptive immune system present in the uterus at the time of implantation==
This cartoon graphically depicts the abundance of immune cells and their close proximity with the invading trophoblast. Uterine DCs (uDCs) are localized close to vessels and in proximity to regulatory T cells (Treg). They act as mediators between Tregs and trophoblasts; they support angiogenesis and are responsible for early antigen presentation. Treg in turn are essential for preparing the uterus for implantation; they are responsible for early tolerance toward paternal antigens. Macrophages actively communicate with trophoblasts and support the luteal vascular network. Uterine natural killer cells (uNK cells) are important for tissue remodeling, to promote angiogenesis, and to contribute to the shaping of spiral arteries. Neutrophils and uterine mast cells (uMCs) both support angiogenesis. uMCs also modulate the remodeling of spiral arteries.

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===Reference===
<pubmed>26136750</pubmed>|<ref>PMID 26136750</ref> [http://journal.frontiersin.org/article/10.3389/fimmu.2015.00321/abstract '''frontiers''' in Immunology]

====Copyright====

Copyright © 2015 Zenclussen and Hämmerling.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms

Figure 1:fimmu-06-00321-g001.jpg

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