File:Cells of the innate and adaptive immune system present in the uterus at the time of implantation.jpg

Cells of the innate and adaptive immune system present in the uterus at the time of implantation

This cartoon graphically depicts the abundance of immune cells and their close proximity with the invading trophoblast. Uterine DCs (uDCs) are localized close to vessels and in proximity to regulatory T cells (Treg). They act as mediators between Tregs and trophoblasts; they support angiogenesis and are responsible for early antigen presentation. Treg in turn are essential for preparing the uterus for implantation; they are responsible for early tolerance toward paternal antigens. Macrophages actively communicate with trophoblasts and support the luteal vascular network. Uterine natural killer cells (uNK cells) are important for tissue remodeling, to promote angiogenesis, and to contribute to the shaping of spiral arteries. Neutrophils and uterine mast cells (uMCs) both support angiogenesis. uMCs also modulate the remodeling of spiral arteries.

(Original figure legend)

Reference

<pubmed>26136750</pubmed>|^[1] frontiers in Immunology

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Figure 1:fimmu-06-00321-g001.jpg

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