File:Ago2 in Mammalian Gastrulation.png

The Homozygous Disruption of Ago2 Results in a Disruption of FGF Signaling

(A−F) Whole-mount in situ hybridization using an antisense probe against Fgf8, Eomesodermin, or Bmp4 on e7.5 wild-type (A, C, E) and Ago2–/– (B, D, F) embryo littermates. The Ago2–/– embryos exhibit a lateral expansion of Fgf8 and Eomesodermin expression away from the primitive streak (B, D; block-arrow). In contrast, the localization of Bmp4 expression is indistinguishable between wild-type (E) and Ago2–/– (F) embryo littermates. (A−D) Embryos imaged with reflective light. (E, F) Embryos imaged with reflective and transmitted light. The scale bar represents 200 μm.

http://dx.doi.org/10.1371/journal.pgen.0030227.g004

Reference

<pubmed>18166081</pubmed>

Copyright

© 2007 Alisch et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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