2016 Group Project 3

2016 Student Projects
Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta
2016 Group Project Topic - Signaling in Development OK you are now in a group, add a topic with your student signature to the group page.
This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements.

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Fibroblast growth factor receptor (FGFR) pathway

History

I have found an article regarding history below, so I will do this section and help out with the nature of FGFR. James will do this section

The Nature of the FGFR Pathway

Two people can work on this section and start looking for articles. One person per subheading.

Introduction to FGF

(VERY BRIEF SUM, NOT FINISHED) The Fibroblast Growth Factor (FGF) signalling pathway is composed of 18 secreted signalling proteins (secreted FGFs, including FGF1 to FGF10, and FGF16 to FGF23) that interact with 4 signalling Tyrosine Kinase FGF Receptors (FGFRs) and other intracellular non-signalling proteins (iFGFs). This family of growth factors are involved in the regulation of early embryonic developmental processes and are pivotal to normal organ, vascular and skeletal development – they are involved in maintaining progenitor cells and regulating their proliferation, differentiation, survival and patterning. They are also involved in maintaining adult tissues by regulating metabolic functions, tissue repair and regeneration – often by reactivating the same signaling pathways that are involved in development.

What is the FGFR Pathway?

(Kristy)

How is the FGFR signalling pathway important in embryonic development?

(Jocelyn)

References

Useful review articles that may be worth a read through:

http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/full

http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrd/journal/v8/n3/pdf/nrd2792.pdf

http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160605006184

http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrm/journal/v14/n3/full/nrm3528.html

http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1002/jcp.24649/full

http://genesdev.cshlp.org/content/29/14/1463.full (FGF signalling and skeletogenesis, specifically how mutations to the FGF signalling pathway may be responsible for skeletal diseases)

Comments by Group 3

Z5015686 (talk) 12:36, 19 August 2016 (AEST) I thought looking into how prenatal cannabis exposure influences signalling during development might be interesting

Z5017002 (talk) 12:47, 19 August 2016 (AEST) Ooh cool idea, I agree that looks really interesting, there seems to be a lot of literature about its influence on brain development

Z5015544 (talk)z5015544Z5015544 (talk) Thats excellent, what about the sonic hedgehog pathway?

Z5015544 (talk)Other ideasZ5015544 (talk) WNT Signaling Pathway is another one to look at

How can we harvest stem cells from the embyro for use in later life - z5015337