Difference between revisions of "2014 Group Project 1"

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===The fetal respiratory system as target for antenatal therapy===
 
===The fetal respiratory system as target for antenatal therapy===
 
<pubmed>24753844</pubmed>
 
<pubmed>24753844</pubmed>
 
==Lung morphogenesis revisited: old facts, current ideas==
 
<pubmed>11002333</pubmed>
 
 
 
Classical ideas -4 basic rules vs their review
 
 
 
  
 
==Genetic control of lung development==
 
==Genetic control of lung development==

Revision as of 23:51, 26 August 2014

2014 Student Projects
2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8
The Group assessment for 2014 will be an online project on Fetal Development of a specific System.

This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements.

Respiratory

Introduction

Airway and blood vessel interaction during lung development.

A retinoic acid–dependent network in the foregut controls formation of the mouse lung primordium.

Lung epithelial branching program antagonizes alveolar differentiation.


Current Research, Models and Findings

Physiological factors in fetal lung growth

<pubmed>3052746</pubmed>


This article looks at the current findings of different physiological factors that affect normal neonatal, functioning lungs upon during fetal development. The size of the paired organ to be able to exchange carbon dioxide with oxygen for the very first time at birth, is crucial to be able to withstand that pressure. As we know surfactant, is a lipid-protein composite. It is crucial to the function of the neonatal lung because:

A. Its high viscosity and low surface tension stabilize the diameter of the alveoli and prevent their collapse after each expiration.

B. Because the alveoli remain partially open, they are expanded on inspiration with much less expenditure of energy. [ANAT 2241 LEC 11-Respriation]

However, current research suggests that the production of surfactant which is reliant on hormonal factors, have little influence on fetal lung growth. In contrast, the following physiological lung growth factors were found to permit the lungs to express their inherent growth potential.

[this will be looked at further as the research project progresses]


Lung morphogenesis revisited: old facts, current ideas

<pubmed>11002333</pubmed>


Classical ideas -4 basic rules vs their review


Genetic control of lung development

<pubmed>12890942</pubmed>


Current concepts of lung development


Effects of hormones on fetal lung development

<pubmed>15550344</pubmed>


The fetal respiratory system as target for antenatal therapy

<pubmed>24753844</pubmed>

Genetic control of lung development

<pubmed>12890942</pubmed>


Current concepts of lung development


Effects of hormones on fetal lung development

<pubmed>15550344</pubmed>


The fetal respiratory system as target for antenatal therapy

<pubmed>24753844</pubmed>

Historic findings

Abnormalities

<pubmed>22151899</pubmed> <pubmed>22214468</pubmed> <pubmed>12547712</pubmed>

Congenital Diaphragmatic Hernia

Laryngo-tracheo-oesophageal clefts


Timeline/Overview