File:Variations of Cleft Lip or Palate.jpg

Figure 2 Types of cleft A: A collection of images of different types of clefts, some with associated anomalies such as lip pits.111 a–c, Van der Woude syndrome cases with associated lip pits; d, isolated cleft palate only; e, isolated unilateral cleft lip and palate; f–m, syndromic forms of clefting (f, CLP in Smith-Lemli-Opitz syndrome; g, midline cleft in holoproencephaly; h, bilateral CLP in TGIF mutation case and I, bilateral CLP in SHH variant; j, midline notch in OFD type 1; k, repaired cleft in MID1 mutation; l, repaired unilateral CLP and; m, pseudo cleft lip). [Legend to be modified depending on images provided. Include image permission details.] B: A set of illustrative drawings of CLP types.111 a and e show unilateral and bilateral clefts of the soft palate; b, c and d show degrees of unilateral cleft lip and palate; f, g and h show degrees of bilateral cleft lip and palate. This figure is modified from REF. 111, with permission. Copyright Macmillan 2002.

Permission: Reprinted by permission from Macmillan Publishers Ltd: [Nature] (Michael J. Dixon,1 Mary L. Marazita,2 Terri H. Beaty,3 and Jeffrey C. Murray, Cleft lip and palate: synthesizing genetic and environmental influences, Nat Rev Genet. 2011 March; 12(3): 167–178. ), copyright (2011)

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086810/?tool=pubmed