2009 Group Project 4

From Embryology
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MOUSE

Timeline of Development

Staging

Mouse embryonic development commences once the female's egg or oocyte has become fertilized by the male's sperm. Mouse development has a gestation period of 19-21 days, and can range in different strains of mice. The development of an embryo can be categorized into different stages including cell number, somite stages and morphology. The most common method of staging is by Theiler which categorizes mouse development into prenatal and postnatal stages consisting of 26 and 2 stages respectively.

Table 1: Mouse embryonic stages of development from fertilization to zona free blastocyst (Stages 1 to 5)
Theiler Stage Embryonic Age in Days Post Coitum (dpc) Stage Characteristic Cell Characteristics Zona Pellucida Location
1 0-0.9

(range 0-0.25)

One-celled embryo (fertilized) One cell Present Ampulla
2 1

(range 1-2.5)

Dividing egg 2-4 cells

- 1st cleavage after 24hrs

Present Travelling down oviduct
3 2

(range 1-3.5)

Morula (early to fully compacted) 4-16 cells Present Oviduct. Usually near utero-tubal junction.
4 3

(range 2-4)

Change from Morula to Blastocyst

-Intra-cellular matrix present -Blastocoelic cavity evident

16-40 compacted cells

-Inner cell mass -Outer layer of trophectoderm cells

Present Uterine lumen
5 4

(range 3-5.5)

Zona free Blastocyst (hatching) Blastocyst is ready to implant as surrounding cell layer of zona pelludica is lost Absent Uterine lumen

Dr Mark Hill 2009, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

History of Model Use

Genetics

Current Embryology Research

References



ANAT2341 group projects

Project 1 - Rabbit | Project 2 - Fly | Project 3 - Zebrafish | Group Project 4 - Mouse | Project 5 - Frog | Students Page | Animal Development