2016 Group Project 3
2016 Student Projects | ||||
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Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta | ||||
2016 Group Project Topic - Signaling in Development
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This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements. |
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Science Student Projects
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History
Fibroblast growth factor (FGF) was initially discovered in pituitary extracts through experiments conducted in 1973. Researchers had noticed the growth stimulating effects that these isolated factors had, in that they induced fibroblast proliferation. Due to their ability to stimulate fibroblast proliferation they were termed "FGFs". Today, a variety of subtypes of FGFs have been discovered and categorised into a large family that exist in organisms including humans as well as nematodes. In addition, it was soon discovered that not all FGFs can stimulate fibroblasts.
The Nature of the FGFR Pathway
Two people can work on this section and start looking for articles. One person per subheading.
Introduction to FGF
(VERY BRIEF SUM, NOT FINISHED)
The Fibroblast Growth Factor (FGF) signalling pathway is composed of 18 secreted signalling proteins (secreted FGFs, including FGF1 to FGF10, and FGF16 to FGF23) that interact with 4 signalling Tyrosine Kinase FGF Receptors (FGFRs) and other intracellular non-signalling proteins (iFGFs). This family of growth factors are involved in the regulation of early embryonic developmental processes and are pivotal to normal organ, vascular and skeletal development – they are involved in maintaining progenitor cells and regulating their proliferation, differentiation, survival and patterning. They are also involved in maintaining adult tissues by regulating metabolic functions, tissue repair and regeneration – often by reactivating the same signaling pathways that are involved in development.
What is the structure of a typical FGFR?
What is the FGFR Pathway?
(Kristy)
How is the FGFR signalling pathway important in embryonic development?
(Jocelyn)
References
Useful review articles that may be worth a read through:
http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/full
http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrd/journal/v8/n3/pdf/nrd2792.pdf
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160605006184
http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrm/journal/v14/n3/full/nrm3528.html
http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1002/jcp.24649/full
http://genesdev.cshlp.org/content/29/14/1463.full (FGF signalling and skeletogenesis, specifically how mutations to the FGF signalling pathway may be responsible for skeletal diseases)