File:Roles and Regulation of SOX2 in Blastocyst Formation.jpeg

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Image title	The roles and regulation of SOX2 during blastocyst formation.A) At the 16-cell stage, when ICM progenitors first arise, HIPPO pathway members regulate expression of TE (Cdx2) and ICM (Sox2) genes in parallel. At this stage, OCT4 and NANOG are still expressed ubiquitously. B) In the blastocyst, Sox2 expression is restricted to EPI cells by FGFR/MEK signaling. In EPI cells, SOX2 helps promote expression of Fgf4, which signals to neighboring cells to induce expression of PE genes. In PE cells, MAPK promotes PE gene expression in an Oct4-dependent manner [3], [13], [59], and represses expression of Sox2 and Nanog in PE cells either directly or indirectly. C) In the late blastocyst, SOX2 helps maintain expression of pluripotency genes, and FGF4, or other signals from EPI, maintain expression of PE genes in neighboring cells.
Copyright holder	Creative Commons Attribution License
Date(s)	23 October 2014
Publisher	Public Library of Science
Short title	Figure 7
Source	info:doi/10.1371/journal.pgen.1004618
Identifier	info:doi/info:doi/10.1371/journal.pgen.1004618.g007