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1. In vitro fertilisation (IVF) has its origins in the 1970s, specifically 1978 when the first successful birth of an IVF baby occurred. This birth was the result of the work of physiologist [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2010/edwards.html Robert G. Edwards], who developed the technique and subsequently won the [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2010/ Nobel Prize in Physiology or Medicine 2010] for his work. The procedure involves removing a healthy ovum from the mother and fertilising it outside of the female's body, where the term ''in vitro'', which is Latin for "in glass" comes from. Today, this term is used to describe any procedure that takes place outside of the body, in opposition to an ''in vivo'' procedure which takes place inside the body. The zygote is then implanted back into the woman's uterus where it can develop normally.<ref>http://en.wikipedia.org/wiki/In_vitro_fertilisation</ref> | 1. In vitro fertilisation (IVF) has its origins in the 1970s, specifically 1978 when the first successful birth of an IVF baby occurred. This birth was the result of the work of physiologist [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2010/edwards.html Robert G. Edwards], who developed the technique and subsequently won the [http://www.nobelprize.org/nobel_prizes/medicine/laureates/2010/ Nobel Prize in Physiology or Medicine 2010] for his work. The procedure involves removing a healthy ovum from the mother and fertilising it outside of the female's body, where the term ''in vitro'', which is Latin for "in glass" comes from. Today, this term is used to describe any procedure that takes place outside of the body, in opposition to an ''in vivo'' procedure which takes place inside the body. The zygote is then implanted back into the woman's uterus where it can develop normally.<ref>http://en.wikipedia.org/wiki/In_vitro_fertilisation</ref> | ||
2. A recent paper published on the topic of fertilisation includes a paper from researchers at the University of Pisa in Italy entitled ''DHEA supplementation improves follicular microenviroment in poor responder patients''.<ref><pubmed>22835219</pubmed></ref> | 2. A recent paper published on the topic of fertilisation includes a paper from researchers at the University of Pisa in Italy entitled ''DHEA supplementation improves follicular microenviroment in poor responder patients''.<ref><pubmed>22835219</pubmed></ref> This study looked at a group of 24 women aged between 31 and 42 diagnosed with poor ovarian response (POR) in which fewer follicles properly develop. These women were randomly split into two groups; one of which received no special treatment prior to IVF, while the other group received dehydroepiandrosterone (DHEA) supplementation, which was hypothesised to increase the quality of the oocytes and therefore increase the chance of a successful pregnancy. | ||
The results showed that the group of women that received DHEA supplementation prior to IVF had lower levels of HIF1 in their follicular fluid; a substance produced by the body in response to low oxygen levels. This suggests that DHEA increases the supply of oxygen to the developing follicle and thus increases its quality, as it had been previously shown that oxygen plays a very important role in follicle development. Although the study demonstrated with statistical significance that supplementation with DHEA led to higher levels of HIF1, it could not be shown that supplementation led to better IVF outcomes, however this was attributed to the small sample size. The study concluded that DHEA supplementation is a viable option to increasing follicle development in women with POR as it is relatively cheap, easily administered and has minimal side effects. | |||
===References=== | ===References=== | ||
<references/> | <references/> | ||
Revision as of 16:01, 30 July 2012
Lab Attendance
Lab 1 -- Z3373894 11:49, 25 July 2012 (EST)
Lab 1 Assessment
1. In vitro fertilisation (IVF) has its origins in the 1970s, specifically 1978 when the first successful birth of an IVF baby occurred. This birth was the result of the work of physiologist Robert G. Edwards, who developed the technique and subsequently won the Nobel Prize in Physiology or Medicine 2010 for his work. The procedure involves removing a healthy ovum from the mother and fertilising it outside of the female's body, where the term in vitro, which is Latin for "in glass" comes from. Today, this term is used to describe any procedure that takes place outside of the body, in opposition to an in vivo procedure which takes place inside the body. The zygote is then implanted back into the woman's uterus where it can develop normally.[1]
2. A recent paper published on the topic of fertilisation includes a paper from researchers at the University of Pisa in Italy entitled DHEA supplementation improves follicular microenviroment in poor responder patients.[2] This study looked at a group of 24 women aged between 31 and 42 diagnosed with poor ovarian response (POR) in which fewer follicles properly develop. These women were randomly split into two groups; one of which received no special treatment prior to IVF, while the other group received dehydroepiandrosterone (DHEA) supplementation, which was hypothesised to increase the quality of the oocytes and therefore increase the chance of a successful pregnancy.
The results showed that the group of women that received DHEA supplementation prior to IVF had lower levels of HIF1 in their follicular fluid; a substance produced by the body in response to low oxygen levels. This suggests that DHEA increases the supply of oxygen to the developing follicle and thus increases its quality, as it had been previously shown that oxygen plays a very important role in follicle development. Although the study demonstrated with statistical significance that supplementation with DHEA led to higher levels of HIF1, it could not be shown that supplementation led to better IVF outcomes, however this was attributed to the small sample size. The study concluded that DHEA supplementation is a viable option to increasing follicle development in women with POR as it is relatively cheap, easily administered and has minimal side effects.
References
- ↑ http://en.wikipedia.org/wiki/In_vitro_fertilisation
- ↑ <pubmed>22835219</pubmed>
