2016 Group Project 3: Difference between revisions
No edit summary |
|||
Line 29: | Line 29: | ||
==Animal Models== | |||
==Abnormalities== | |||
(Kristine) | |||
==References== | ==References== |
Revision as of 18:38, 14 September 2016
2016 Student Projects | ||||
---|---|---|---|---|
Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta | ||||
2016 Group Project Topic - Signaling in Development
OK you are now in a group, add a topic with your student signature to the group page. | ||||
This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements. |
Group Assessment Criteria |
---|
Science Student Projects
|
More Information on Assessment Criteria | Science Student Projects |
Fibroblast Growth Factor Receptor (FGFR) Pathway
Introduction
The Fibroblast Growth Factor (FGF) signalling pathway is critical for regulating progenitor cell proliferation, differentiation, survival and patterning. It is involved in the regulation and development of the early embryo, and is considered to be critical for normal organ, vascular and skeletal development. Furthermore, this pathway is also involved in maintaining adult tissues through the regulation of metabolic functions and tissue repair (which is often through the reactivation of the same signalling pathways involved in early development.) PMID 25772309
History
Fibroblast growth factor (FGF) was initially discovered in pituitary extracts through experiments conducted in 1973. Researchers had noticed the growth stimulating effects that these isolated factors had, in that they induced fibroblast proliferation. Due to their ability to stimulate fibroblast proliferation they were termed "FGFs". Today, a variety of subtypes of FGFs have been discovered and categorised into a large family that exist in organisms including humans as well as nematodes. In addition, it was soon discovered that not all FGFs can stimulate fibroblasts.
Overview Of The FGFR Pathway
Role In Embryonic Development
Patterning Of The Embryonic Axis
Induction/Maintenance Of Mesoderm And Neuroectoderm
Organogenesis
Limb Bud
(Kristine)
Kidney/External Genitalia
Animal Models
Abnormalities
(Kristine)
References
Extra Resources
Useful review articles that may be worth a read through:
http://onlinelibrary.wiley.com/doi/10.1002/wdev.176/full
http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrd/journal/v8/n3/pdf/nrd2792.pdf
http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0012160605006184
http://www.nature.com.wwwproxy0.library.unsw.edu.au/nrm/journal/v14/n3/full/nrm3528.html
http://onlinelibrary.wiley.com.wwwproxy0.library.unsw.edu.au/doi/10.1002/jcp.24649/full
http://genesdev.cshlp.org/content/29/14/1463.full (FGF signalling and skeletogenesis, specifically how mutations to the FGF signalling pathway may be responsible for skeletal diseases)