2016 Group Project 6: Difference between revisions
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diagram of the signalling pathway | diagram of the signalling pathway, | ||
tabulate how it is involved in the various processes of embryology | tabulate how it is involved in the various processes of embryology | ||
Revision as of 14:35, 2 September 2016
2016 Student Projects | ||||
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Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta | ||||
2016 Group Project Topic - Signaling in Development
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This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements. |
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TGF beta Signaling Pathway
Brief introduction of topic
Transforming growth factor beta is a multifunctional cytokine, belonging to the transforming growth factor superfamily. A cytokine is a broad and loose category of small proteins that are important in cell signalling The process of the TGF beta signalling is simple - TGFB superfamily ligands (a molecule that binds to a larger molecule) binds to a type II receptor, which recruits and phosphorylates a type I receptor. Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells Type I cytokine receptors are also transmembrane receptors expressed on the surface of cells. They recognize and respond to cytokines with four alpha helical strands. The difference? Type II receptors do not possess the signature sequence WSXWS (which is a characteristic of Type I receptors). NOT FINISHED
http://wormbook.org/chapters/www_tgfbsignal/tgfbsignal.html
* REVIEW ARTICLE
diagram of the signalling pathway, tabulate how it is involved in the various processes of embryology