2011 Group Project 11

Note - This page is an undergraduate science embryology student group project 2011. 2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip

Development of Disease

Developmental Staging

• Two main stages of palate development, primary and secondary
• Morphology of face established between weeks four and five
• 7th week – intermaxillary process formed, Intermaxillary process gives rise to primary palate
• End of 7th week – palantine shelves start to move into position and fuse together to form secondary palate
• Failure of these palantine shelves to fuse results in cleft palate
• Secondary palate fused during 10th week
• Cleft palate results in failure of the two maxillary processes to fuse with the descending part of the intermaxillary process

Abnormality Classification

• There has been a new proposed classification system
• Cleft palate and cleft lip have different embryological origins
• More than 300 syndromes involving facial clefting
• Can be unilateral or bilateral

References

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2011 Projects: Turner Syndrome | DiGeorge Syndrome | Klinefelter's Syndrome | Huntington's Disease | Fragile X Syndrome | Tetralogy of Fallot | Angelman Syndrome | Friedreich's Ataxia | Williams-Beuren Syndrome | Duchenne Muscular Dystrolphy | Cleft Palate and Lip