File talk:Bone marrow histology 01.jpg
The bone marrow vascular niche: home of HSC differentiation and mobilization
Physiology (Bethesda). 2005 Oct;20:349-56.
Kopp HG, Avecilla ST, Hooper AT, Rafii S. Source Weill Medical College of Cornell University, New York, New York, USA.
Abstract
The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
PMID 16174874
Full paper http://physiologyonline.physiology.org/content/20/5/349.full
Arterial vessels
- enter the marrow through foramina nutricia.
- then divide into several arterioles.
- small arterioles and capillaries from these vessels span throughout the bone marrow and supply sinusoids.
Sinusoids
- wall consists of a single layer of endothelial cells and no supporting cells.
- interconnected by intersinusoidal capillaries.
- radially distributed around the draining central sinus (about 100 µm in diameter).
- bone marrow sinusoids are unique and are not comparable with regular veins.
