File:Nociceptor Specification.JPG

Nociceptor specification requires neurtrophins binding to TrkA receptors of neurons in the Dorsal Root Ganglia. Such signalling determines the fate of these neurons to become nociceptors.

This is a Student drawn diagram by z3332863 based on information from:

S N Lawson, T J Biscoe Development of mouse dorsal root ganglia: an autoradiographic and quantitative study. J. Neurocytol.: 1979, 8(3);265-74 PMID:490183 R J Smeyne, R Klein, A Schnapp, L K Long, S Bryant, A Lewin, S A Lira, M Barbacid Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature: 1994, 368(6468);246-9 PMID:8145823 Y Kitao, B Robertson, M Kudo, G Grant Neurogenesis of subpopulations of rat lumbar dorsal root ganglion neurons including neurons projecting to the dorsal column nuclei. J. Comp. Neurol.: 1996, 371(2);249-57 PMID:8835730 Aziz Moqrich, Taryn J Earley, James Watson, Mary Andahazy, Carey Backus, Dionisio Martin-Zanca, Douglas E Wright, Louis F Reichardt, Ardem Patapoutian Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat. Neurosci.: 2004, 7(8);812-8 PMID:15247919 Claudia Lopes, Zijing Liu, Yi Xu, Qiufu Ma Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J. Neurosci.: 2012, 32(28);9706-15 PMID:22787056 Frédéric Marmigère, Andreas Montelius, Michael Wegner, Yoram Groner, Louis F Reichardt, Patrik Ernfors The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons. Nat. Neurosci.: 2006, 9(2);180-7 PMID:16429136 Note - This image was originally uploaded as part of an undergraduate science student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal. Copyright: This is a student drawn image and free for non-profit reuse.