ANAT2341 Lab 5

From Embryology

1. QUIZ

2. Guest Lecturer - Dr. Vashe Chandrakanthan

Vashe Chandrakanthan profile photo.jpg

Dr. Vashe Chandrakanthan

Cardiac and Vascular Development and Haematopoiesis


Dr Vashe Chandrakanthan earned his PhD in Medicine from University of Sydney and completed his postdoctoral studies at the Victor Chang Cardiac Research Institute in Sydney.

Currently he is a Research Fellow at the Lowy Cancer Research Centre at the UNSW Australia. He is a member of the adult cancer program where he heads the mesenchymal stem cell biology team. He joined the stem cell program to help setting up a regenerative medicine program at the UNSW Australia.

Dr Chandrakanthan’s primary research interest lies in the field of developmental and molecular biology of stem cells. During his tenure at the Lowy Cancer Research Centre, in addition to setting up the regenerative medicine program, he has lineage traced mesenchymal stem cells and evaluated their contribution to various tissues in the mouse embryo with a particular focus on their role in haematopoiesis.


Lecture Slides

References

Search PubMed: Chandrakanthan V

Vashe Chandrakanthan, Avani Yeola, Jair C Kwan, Rema A Oliver, Qiao Qiao, Young Chan Kang, Peter Zarzour, Dominik Beck, Lies Boelen, Ashwin Unnikrishnan, Jeanette E Villanueva, Andrea C Nunez, Kathy Knezevic, Cintia Palu, Rabab Nasrallah, Michael Carnell, Alex Macmillan, Renee Whan, Yan Yu, Philip Hardy, Shane T Grey, Amadeus Gladbach, Fabien Delerue, Lars Ittner, Ralph Mobbs, Carl R Walkley, Louise E Purton, Robyn L Ward, Jason W H Wong, Luke B Hesson, William Walsh, John E Pimanda PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proc. Natl. Acad. Sci. U.S.A.: 2016; PubMed 27044077

Julie A I Thoms, Kathy Knezevic, Jia Jenny Liu, Elias N Glaros, Thuan Thai, Qiao Qiao, Heather Campbell, Deborah Packham, Yizhou Huang, Peter Papathanasiou, Robert Tunningley, Belinda Whittle, Amanda W S Yeung, Vashe Chandrakanthan, Luke Hesson, Vivien Chen, Jason W H Wong, Louise E Purton, Robyn L Ward, Shane R Thomas, John E Pimanda Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr. Mol. Cell. Biol.: 2016, 36(8);1222-36 PubMed 26830229

Y Huang, J A I Thoms, M L Tursky, K Knezevic, D Beck, V Chandrakanthan, S Suryani, J Olivier, A Boulton, E N Glaros, S R Thomas, R B Lock, K L MacKenzie, J H Bushweller, J W H Wong, J E Pimanda MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation. Leukemia: 2016, 30(7);1552-61 PubMed 27055868

Jonathon Marks-Bluth, Anchit Khanna, Vashe Chandrakanthan, Julie Thoms, Thomas Bee, Christina Eich, Young Chan Kang, Kathy Knezevic, Qiao Qiao, Simon Fitch, Leif Oxburgh, Katrin Ottersbach, Elaine Dzierzak, Marella F T R de Bruijn, John E Pimanda SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development. Mol. Cell. Biol.: 2015, 35(12);2165-72 PubMed 25870111


3. Group Project

We will review progress on each of the group projects to date.

  • What is working?
  • Where are the problems?
  • What help is needed?

Remember that each Group has their own discussion area on Moodle and should be using this for discussions.

 2017 ANAT2341 - Timetable | Course Outline | Group Projects | Moodle | Tutorial 1 | Tutorial 2 | Tutorial 3

Labs: 1 Fertility and IVF | 2 ES Cells to Genome Editing | 3 Preimplantation and Early Implantation | 4 Reproductive Technology Revolution | 5 Cardiac and Vascular Development | 6 CRISPR-Cas9 | 7 Somitogenesis and Vertebral Malformation | 8 Organogenesis | 9 Genetic Disorders | 10 Melanocytes | 11 Stem Cells | 12 Group

Lectures: 1 Introduction | 2 Fertilization | 3 Week 1/2 | 4 Week 3 | 5 Ectoderm | 6 Placenta | 7 Mesoderm | 8 Endoderm | 9 Research Technology | 10 Cardiovascular | 11 Respiratory | 12 Neural crest | 13 Head | 14 Musculoskeletal | 15 Limb | 16 Renal | 17 Genital | 18 Endocrine | 19 Sensory | 20 Fetal | 21 Integumentary | 22 Birth | 23 Stem cells | 24 Revision

 Student Projects: 1 Cortex | 2 Kidney | 3 Heart | 4 Eye | 5 Lung | 6 Cerebellum