Musculoskeletal System - Muscle Development
Introduction
There are 3 different types of muscle: skeletal, cardiac and smooth. This page describes skeletal muscle development, descriptions of cardiac muscle and smooth muscle development can be found in other notes. (More? Cardiac or GIT Development)
Skeletal muscle forms by fusion of mononucleated myoblasts to form mutinucleated myotubes.
Differentiation/determination of mesoderm into muscle cells is thought to involve a family of basic Helix-Loop-Helix transcription factors, the first of which discovered was MyoD1. (see OMIM entry). It needs to form a dimer to be active and is maintained in an inactive state by binding of Id (see OMIM entry).
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--Mark Hill 09:25, 14 April 2010 (EST) Page Template only - content from original UNSW Embryology site currently being edited and updated.
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Cite this page: Hill, M.A. (2024, May 19) Embryology Musculoskeletal System - Muscle Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Musculoskeletal_System_-_Muscle_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G