ANAT2341 Lab 4

Endoderm Development

2. Guest Lecturer Dr. Nicolas Fossat (CMRI) - Endoderm, RNA biology and gut organoids

Doctor Nicolas Fossat is a Research Fellow in Professor Patrick Tam’s laboratory, in the Embryology Unit, Children’s Medical Research Institute.

Dr Fossat completed his PhD in 2005 at the Ecole Normale Superieure of Lyon in France. During this period, he studied the homeodomain transcription factor Otx2 which is coded by one of the few master genes essential for the formation of the head. Notably, using the latest tools of molecular biology, he developed a novel genetic approach called “conditional self-knockout” allowing the inactivation of the Otx2 gene at anytime and anywhere in the mouse. His background is a strong understanding of and an easy ability to manipulate the mouse embryo genome. In 2007, he joined Professor Patrick Tam’s team. Professor Tam is a pioneer in mouse embryo manipulation. In his lab, he pursues his understanding of the formation of the head. He focuses on the intersection of transcriptional and signalling activities by studying the interaction of another important actor of the formation of the head, the master gene Lhx1, and a fundamental pathway, the WNT signalling pathway which is crucial in every part of the body for the control of cell proliferation and cell differentiation. In addition, he works on the foregut endoderm which is also important for the formation of the head as well as for the establishment of organs involved in secretory or absorptive functions, such as the thyroid, pancreas and the liver. With the ultimate goal to cure diseases affecting these organs such as hypo/hyper-thyroidism or diabetes, he has started to study the function of an unknown gene that Patrick Tam’s lab has identified as specifically active in the foregut endoderm. This new gene codes a RNA-binding protein which has led me to also take a great interest in RNA and miRNA functions.

References

ANAT2341 Course Timetable   Week (Mon) Lecture 1 (Mon 1-2pm) Lecture 2 (Tue 3-4pm) Practical (Fri 1-3pm) Week 2 (1 Aug) Introduction Fertilization Lab 1 Week 3 (8 Aug) Week 1 and 2 Week 3 Lab 2 Week 4 (15 Aug) Mesoderm Ectoderm Lab 3 Week 5 (22 Aug) Early Vascular Placenta Lab 4 Week 6 (29 Aug) Gastrointestinal Respiratory Lab 5 Week 7 (5 Sep) Head Neural Crest Lab 6 Week 8 (12 Sep) Musculoskeletal Limb Development Lab 7 Week 9 (19 Sep) Renal Genital Lab 8 Mid-semester break Week 10 (3 Oct) Public Holiday Stem Cells Lab 9 Week 11 (10 Oct) Integumentary Endocrine Lab 10 Week 12 (17 Oct) Heart Sensory Lab 11 Week 13 (24 Oct) Fetal Birth and Revision Lab 12 ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016

ANAT2341Lectures - Textbook chapters   Lecture (Timetable) Textbook - The Developing Human Textbook - Larsen's Human Embryology Embryology Introduction Introduction to the Developing Human Fertilization First Week of Human Development Gametogenesis, Fertilization, and First Week Week 1 and 2 Second Week of Human Development Second Week: Becoming Bilaminar and Fully Implanting Week 3 Third Week of Human Development Third Week: Becoming Trilaminar and Establishing Body Axes Mesoderm Fourth to Eighth Weeks of Human Development Fourth Week: Forming the Embryo Ectoderm Nervous System Development of the Central Nervous System Early Vascular Cardiovascular System Development of the Vasculature Placenta Placenta and Fetal Membranes Development of the Vasculature Endoderm - GIT Alimentary System Development of the Gastrointestinal Tract Respiratory Respiratory System Development of the Respiratory System and Body Cavities Head Pharyngeal Apparatus, Face, and Neck Development of the Pharyngeal Apparatus and Face Neural Crest Nervous System Development of the Peripheral Nervous System Musculoskeletal Muscular System Development of the Musculoskeletal System Limb Development of Limbs Development of the Limbs Renal Urogenital System Development of the Urinary System Genital Urogenital System Development of the Urinary System Stem Cells Integumentary Integumentary System Development of the Skin and Its Derivatives Endocrine Covered through various chapters (see also alternate text), read head and neck, neural crest and renal chapters. Endocrinology Textbook - Chapter Titles   Nussey S. and Whitehead S. Endocrinology: An Integrated Approach (2001) Oxford: BIOS Scientific Publishers; ISBN-10: 1-85996-252-1. Chapter 1. Principles of endocrinology Chapter 2. The endocrine pancreas Chapter 3. The thyroid gland Chapter 4. The adrenal gland Chapter 5. The parathyroid glands and vitamin D Chapter 6. The gonad Chapter 7. The pituitary gland Chapter 8. Cardiovascular and renal endocrinology Full Table of Contents Heart Cardiovascular System Development of the Heart Sensory Development of Eyes and Ears Development of the Eyes Fetal Fetal Period Fetal Development and the Fetus as Patient Birth and Revision Additional Textbook Content - The following concepts also form part of the theory material covered throughout the course. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis Common Signaling Pathways Used During Development Human Birth Defect

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Cite this page: Hill, M.A. (2024, May 22) Embryology ANAT2341 Lab 4. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/ANAT2341_Lab_4

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G