Talk:Human Chorionic Gonadotropin

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Cite this page: Hill, M.A. (2024, June 14) Embryology Human Chorionic Gonadotropin. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Talk:Human_Chorionic_Gonadotropin

2012

hCG, the wonder of today's science

Reprod Biol Endocrinol. 2012 Mar 28;10:24.

Cole LA. Source USA hCG Reference Service, Albuquerque NM 87104, USA. larry@hcglab.com.

Abstract

ABSTRACT: BACKGROUND: hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. CONTENT: These 5 molecules, hCG, sulfated hCG, hyperglycosylated hCG, hCG free beta and hyperglycosylated free beta are produced by placental syncytiotrophoblast cells and pituitary gonadotrope cells (group 1), and by placental cytotrophoblast cells and human malignancies (group 2). Group 1 molecules are both hormones that act on the hCG/LH receptor. These molecules are central to human menstrual cycle and human pregnancy. Group 2 molecules are autocrines, that act by antagonizing a TGF beta receptor. These molecules are critical to all advanced malignancies. CONCLUSIONS: The hCG groups are molecules critical to both the molecules of pregnancy or human life, and to the advancement of cancer, or human death.

PMID 22455390

http://www.rbej.com/content/10/1/24

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