Penis Development: Difference between revisions
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| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | | [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}} | ||
Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Embryology ''Penis Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Development ''Penis Development''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Embryology ''Penis Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Development ''Penis Development''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Hypospadias ''Hypospadias''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epispadias ''Epispadias''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penile+Urethra+Development ''Penile Urethra Development''] | ||
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===Epispadias=== | ===Epispadias=== | ||
Uncommon abnormality associated with the penis, 1 in 30,000 infant males, external urethral opening on the dorsal surface of penis. | Uncommon abnormality associated with the penis, 1 in 30,000 infant males, external urethral opening on the dorsal surface of penis. | ||
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| {{ICD-11}} {{ICD11weblink}}397402420 LB55 Epispadias] - ''Epispadias is a congenital genitourinary malformation belonging to the spectrum of the exstrophy-epispadias complex and is characterized in males by an ectopic meatus or a mucosal strip in place of the urethra on the penile dorsum and in females by bifid clitoris and a variable cleft of the urethra.'' | |||
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Revision as of 11:58, 2 May 2019
Embryology - 29 May 2024 Expand to Translate |
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Introduction
The external male genitalia consists of the penis and scrotum containing the testis.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Penis Embryology | Penis Development | Hypospadias | Epispadias | Penile Urethra Development |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page.
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Movies
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Mesonephic Duct Development
The paired mesonephic ducts (Wolffian ducts) go through a series of developmental changes to form the male internal genital tract.
Initiation
Invagination
Elongation
- Links:
Foreskin Development
Foreskin development occurs during the second trimester.[7]
- GA week 12 (Week 10) - ectoderm circular invagination at the glandular periphery now grows ventrally.
- GA week 13 (Week 12) - glans partially covered by the foreskin.
- GA week 16-17 (Week 14-15) - glans almost completely covered by the foreskin.
- GA week 18-19 (Week 16-17) - complete foreskin was formed.
- GA week 20 (Week 18) - entirely involves the glans.
Postnatal Development
Abnormalities
Hypospadias
ICD-11 |
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Hypospadias
Hypospadias, coronal - abnormally placed urinary meatus that opens in the ventral portion of the coronal sulcus. |
External urethral opening on the ventral surface of penis, can extend back into scrotum. Abnormality due to failure of genital fold fusion during fetal development of the male external genitalia.
Hypospadia Classification | Meatus Opening |
Anterior | on inferior surface of glans penis |
Coronal | in balanopenile furrow |
Distal | on distal third of shaft |
Penoscrotal | at base of shaft in front of scrotum |
Scrotal | on scrotum or between the genital swellings |
Perineal | behind scrotum or genital swellings |
Links: Genital Abnormalities | Penis Development |
- Links: hypospadias
Epispadias
Uncommon abnormality associated with the penis, 1 in 30,000 infant males, external urethral opening on the dorsal surface of penis.
ICD-11 LB55 Epispadias - Epispadias is a congenital genitourinary malformation belonging to the spectrum of the exstrophy-epispadias complex and is characterized in males by an ectopic meatus or a mucosal strip in place of the urethra on the penile dorsum and in females by bifid clitoris and a variable cleft of the urethra. |
Endocrine Disruptors
Endocrine disruptors in female reproductive tract development and carcinogenesis.[8]
Additional Images
Historic
References
- ↑ Shen J, Isaacson D, Cao M, Sinclair A, Cunha GR & Baskin L. (2018). Immunohistochemical expression analysis of the human fetal lower urogenital tract. Differentiation , 103, 100-119. PMID: 30287094 DOI.
- ↑ Baskin L, Shen J, Sinclair A, Cao M, Liu X, Liu G, Isaacson D, Overland M, Li Y & Cunha GR. (2018). Development of the human penis and clitoris. Differentiation , 103, 74-85. PMID: 30249413 DOI.
- ↑ Liu G, Liu X, Shen J, Sinclair A, Baskin L & Cunha GR. (2018). Contrasting mechanisms of penile urethral formation in mouse and human. Differentiation , 101, 46-64. PMID: 29859371 DOI.
- ↑ Shen J, Overland M, Sinclair A, Cao M, Yue X, Cunha G & Baskin L. (2016). Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra. Differentiation , 92, 169-182. PMID: 27397682 DOI.
- ↑ Ishiguro T, Tamagawa S & Ogawa H. (1992). [Changes of pupil size in brain death patients]. Seishin Shinkeigaku Zasshi , 94, 864-73. PMID: 1484906
- ↑ Gallo CB, Costa WS, Furriel A, Bastos AL & Sampaio FJ. (2014). Modifications of erectile tissue components in the penis during the fetal period. PLoS ONE , 9, e106409. PMID: 25170760 DOI.
- ↑ Favorito LA, Balassiano CM, Costa WS & Sampaio FJ. (2012). Development of the human foreskin during the fetal period. Histol. Histopathol. , 27, 1041-5. PMID: 22763876 DOI.
- ↑ <pubmed>19709900</pubmed>
Reviews
Cunha GR & Baskin L. (2018). Development of human male and female urogenital tracts. Differentiation , 103, 1-4. PMID: 30262219 DOI.
Articles
Liu X, Liu G, Shen J, Yue A, Isaacson D, Sinclair A, Cao M, Liaw A, Cunha GR & Baskin L. (2018). Human glans and preputial development. Differentiation , 103, 86-99. PMID: 30245194 DOI.
Isaacson D, Shen J, Overland M, Li Y, Sinclair A, Cao M, McCreedy D, Calvert M, McDevitt T, Cunha GR & Baskin L. (2018). Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation. Differentiation , 103, 14-23. PMID: 30262218 DOI.
Liu G, Liu X, Shen J, Sinclair A, Baskin L & Cunha GR. (2018). Contrasting mechanisms of penile urethral formation in mouse and human. Differentiation , 101, 46-64. PMID: 29859371 DOI.
Wisniewski H & Terry RD. (1968). Further studies on experimental neurofibrillary tangles. J. Neuropathol. Exp. Neurol. , 27, 149-50. PMID: 5690451
Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | endocrine gonad | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
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Glossary Links
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Cite this page: Hill, M.A. (2024, May 29) Embryology Penis Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Penis_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G