Penis Development: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[File:Male_external_001_icon.jpg|200px|thumb|link=External Genital Male Development Movie|[[Week 9]], the indifferent stage of external genitalia.]] | [[File:Male_external_001_icon.jpg|200px|thumb|link=External Genital Male Development Movie|[[Week 9]], the indifferent stage of external genitalia.]] | ||
The external male genitalia consists of the penis and scrotum containing the testis. | The external male genitalia consists of the {{penis}} and scrotum containing the {{testis}}. | ||
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* '''Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra''' | * '''Development of the human penis and clitoris'''{{#pmid:30249413|PMID30249413}} "The human penis and clitoris develop from the ambisexual genital tubercle. To compare and contrast the development of human penis and clitoris, we used macroscopic photography, optical projection tomography, light sheet microscopy, scanning electron microscopy, histology and immunohistochemistry. The human genital tubercle differentiates into a penis under the influence of androgens forming a tubular urethra that develops by canalization of the urethral plate to form a wide diamond-shaped urethral groove (opening zipper) whose edges (urethral folds) fuse in the midline (closing zipper). In contrast, in females, without the influence of androgens, the vestibular plate (homologue of the urethral plate) undergoes canalization to form a wide vestibular groove whose edges (vestibular folds) remain unfused, ultimately forming the labia minora defining the vaginal vestibule. The neurovascular anatomy is similar in both the developing human penis and clitoris and is the key to successful surgical reconstructions." | ||
* '''Modifications of erectile tissue components in the penis during the fetal period''' | |||
* '''Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra'''{{#pmid:27397682|PMID27397682}} "The opening zipper progresses from proximal to distal along the shaft of the penis and clitoris into the glans in identical fashion in both sexes. The closing zipper mechanism is active only in males and is not a single process but rather a series of layered fusion events, uniquely different from the simple fusion of two epithelial surfaces as occurs in formation of the palate and neural tube." | |||
* '''Modifications of erectile tissue components in the penis during the fetal period'''{{#pmid:25170760|PMID25170760}} "The penile erectile tissue has a complex microscopic anatomy with important functions in the mechanism of penile erection. The knowledge of such structures is necessary for understanding the normal physiology of the adult penis. Therefore, it is important to know the changes of these penile structures during fetal development. This study aims to analyze the development of the main components of the erectile tissue, such as collagen, smooth muscle fibers and elastic system fibers, in human fetuses. We found strong correlation between the elements analyzed with fetal age, both in corpus cavernosum and corpus spongiosum. The growth rate of these elements was more intense during the second trimester (13 to 24 WPC) of gestation, both in corpus cavernosum and in corpus spongiosum. There is greater proportional amount of collagen in the corpus spongiosum than in corpus cavernosum during all fetal period. In the corpus spongiosum, there is about four times more collagen than smooth muscle fibers and elastic system fibers, during all fetal period studied. " | |||
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Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Embryology ''Penis Embryology''] | Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Embryology ''Penis Embryology''] | [http://www.ncbi.nlm.nih.gov/pubmed/?term=Penis+Development ''Penis Development''] | ||
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Revision as of 13:30, 29 January 2019
Embryology - 29 May 2024 Expand to Translate |
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Introduction
The external male genitalia consists of the penis and scrotum containing the testis.
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Penis Embryology | Penis Development |
Movies
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Mesonephic Duct Development
The paired mesonephic ducts (Wolffian ducts) go through a series of developmental changes to form the male internal genital tract.
Initiation
Invagination
Elongation
- Links:
Foreskin Development
Foreskin development occurs during the second trimester.[4]
- GA week 12 (Week 10) - ectoderm circular invagination at the glandular periphery now grows ventrally.
- GA week 13 (Week 12) - glans partially covered by the foreskin.
- GA week 16-17 (Week 14-15) - glans almost completely covered by the foreskin.
- GA week 18-19 (Week 16-17) - complete foreskin was formed.
- GA week 20 (Week 18) - entirely involves the glans.
Postnatal Development
Abnormalities
Hypospadia
External urethral opening on the ventral surface of penis, can extend back into scrotum. Abnormality due to failure of genital fold fusion during fetal development of the male external genitalia.
Hypospadia Classification | Meatus Opening |
Anterior | on inferior surface of glans penis |
Coronal | in balanopenile furrow |
Distal | on distal third of shaft |
Penoscrotal | at base of shaft in front of scrotum |
Scrotal | on scrotum or between the genital swellings |
Perineal | behind scrotum or genital swellings |
Links: Genital Abnormalities | Penis Development |
Epispadias
Uncommon abnormality associated with the penis, 1 in 30,000 infant males, external urethral opening on the dorsal surface of penis.
Endocrine Disruptors
Endocrine disruptors in female reproductive tract development and carcinogenesis.[5]
Additional Images
Historic
References
- ↑ Baskin L, Shen J, Sinclair A, Cao M, Liu X, Liu G, Isaacson D, Overland M, Li Y & Cunha GR. (2018). Development of the human penis and clitoris. Differentiation , 103, 74-85. PMID: 30249413 DOI.
- ↑ Shen J, Overland M, Sinclair A, Cao M, Yue X, Cunha G & Baskin L. (2016). Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra. Differentiation , 92, 169-182. PMID: 27397682 DOI.
- ↑ Gallo CB, Costa WS, Furriel A, Bastos AL & Sampaio FJ. (2014). Modifications of erectile tissue components in the penis during the fetal period. PLoS ONE , 9, e106409. PMID: 25170760 DOI.
- ↑ Favorito LA, Balassiano CM, Costa WS & Sampaio FJ. (2012). Development of the human foreskin during the fetal period. Histol. Histopathol. , 27, 1041-5. PMID: 22763876 DOI.
- ↑ <pubmed>19709900</pubmed>
Reviews
Articles
Wisniewski H & Terry RD. (1968). Further studies on experimental neurofibrillary tangles. J. Neuropathol. Exp. Neurol. , 27, 149-50. PMID: 5690451
Genital Links: genital | Lecture - Medicine | Lecture - Science | Lecture Movie | Medicine - Practical | primordial germ cell | meiosis | endocrine gonad | Genital Movies | genital abnormalities | Assisted Reproductive Technology | puberty | Category:Genital
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Cite this page: Hill, M.A. (2024, May 29) Embryology Penis Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Penis_Development
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G