Week 6

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Key Events of Human Development during the sixth week (week 6) following fertilization or clinical gestational age GA week 8 (LMP).

This week corresponds to Carnegie stages 16 and 17.

Week 6 Links: stage 16 | stage 17 | Lecture - Head | Outflow Tract | Category:Week 6 | GA week 8


Stage 16 Links: Week 6 | Head | Lecture - Limb | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 16 | Week 6 | Next Stage 17
  Historic Papers: 1906 | 1908 | 1948 stages 15-18


Stage 17 Links: Week 6 | System Development | Head | Lecture - Limb | Lecture - Head Development | Lecture - Sensory | Science Practical - Head | Science Practical - Sensory | Science Practical - Urogenital | Carnegie Embryos | Madrid Embryos | Category:Carnegie Stage 17 | Next Stage 18
  Historic Papers: 1926 Precervical Sinus | 1948 stage 15-18


Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

Timeline

Week 6 - Human Embryo Stages and Events (GA week 8) 
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
Day
Stage
Event
36
Pituitary - Week 6 connecting stalk between pouch and oral cavity degenerates

Parathyroid - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation

Thymus - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation

Adrenal - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia

Respire - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes

Tongue Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)

37
Stage 16
Stage16 bf1c.jpg
Neural - first parasympathetic ganglia, submandibular and ciliary, are identifiable[1]

Limbs upper limb bud nerves median nerve, radial nerve and ulnar nerve entered into hand plate, myoblasts spindle shaped and oriented parallel to limb bud axis.

Heart - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions

Head lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.

38
   
39
   
40
   
41
Stage 17
Stage17 bf1c.jpg

Neural - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus[2]

Sense - Smell olfactory nerve fibres enter the brain[3] Neural - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally[4]

Pancreas - rotation of the developing stomach moves ventral bud dorsally and fuses with the dorsal bud.

42
  Heart - separation of common cardiac outflow (aortic arch and pulmonary aorta)
Note - the day timing of stages is only approximate, system names link to first page of that specific system, and events are based upon the literature cited below.
References
  1. F Müller, R O'Rahilly The human brain at stage 16, including the initial evagination of the neurohypophysis. Anat. Embryol.: 1989, 179(6);551-69 PubMed 2751117
  2. F Müller, R O'Rahilly The human brain at stage 17, including the appearance of the future olfactory bulb and the first amygdaloid nuclei. Anat. Embryol.: 1989, 180(4);353-69 PubMed 2802187
  3. F Müller, R O'Rahilly Olfactory structures in staged human embryos. Cells Tissues Organs (Print): 2004, 178(2);93-116 PubMed 15604533
  4. Magdalena Patelska-Banaszewska, Witold Woźniak The development of the epidural space in human embryos. Folia Morphol. (Warsz): 2004, 63(3);273-9 PubMed 15478101
Day
Stage
Event
36
Pituitary - Week 6 connecting stalk between pouch and oral cavity degenerates

Parathyroid - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation

Thymus - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation

Adrenal - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia

Respire - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes

Tongue Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)

37
Stage 16 Stage16 bf1c.jpg Neural - first parasympathetic ganglia, submandibular and ciliary, are identifiable[1]

Limbs upper limb bud nerves median nerve, radial nerve and ulnar nerve entered into hand plate, myoblasts spindle shaped and oriented parallel to limb bud axis.

Heart - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions

Head lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.

38
   
39
   
40
   
41
Stage 17 Stage17 bf1c.jpg

Neural - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus[2]

Sense - Smell olfactory nerve fibres enter the brain[3] Neural - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally[4]

Pancreas - rotation of the developing stomach moves ventral bud dorsally and fuses with the dorsal bud.

42
  Heart - separation of common cardiac outflow (aortic arch and pulmonary aorta)

References

  1. F Müller, R O'Rahilly The human brain at stage 16, including the initial evagination of the neurohypophysis. Anat. Embryol.: 1989, 179(6);551-69 PubMed 2751117
  2. F Müller, R O'Rahilly The human brain at stage 17, including the appearance of the future olfactory bulb and the first amygdaloid nuclei. Anat. Embryol.: 1989, 180(4);353-69 PubMed 2802187
  3. F Müller, R O'Rahilly Olfactory structures in staged human embryos. Cells Tissues Organs (Print): 2004, 178(2);93-116 PubMed 15604533
  4. Magdalena Patelska-Banaszewska, Witold Woźniak The development of the epidural space in human embryos. Folia Morphol. (Warsz): 2004, 63(3);273-9 PubMed 15478101



Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline


Glossary Links

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols



Cite this page: Hill, M.A. 2017 Embryology Week 6. Retrieved September 26, 2017, from https://embryology.med.unsw.edu.au/embryology/index.php/Week_6

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© Dr Mark Hill 2017, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G