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{{Header}}
Key Events of Human Development during the sixth week (week 6) following fertilization or Clinical week 8 (LMP).


:[[Carnegie stage table|'''Carnegie Stages''']]: [[Carnegie_stage_16|16]] | [[Carnegie_stage_17|17]]
Key Events of Human Development during the sixth week ([[:Category:Week 6|week 6]]) following fertilization or clinical gestational age {{GA}} week 8 (LMP).


This week corresponds to [[Carnegie stage table|Carnegie stages]] [[Carnegie_stage_16|16]] and [[Carnegie_stage_17|17]].


{{Week}}
{{Week 6 Links}}
<br>
==Carnegie Stages==
{{Carnegie_stage_table_1}}
<br>
Historic [[Carnegie Stages]] 16 and 17.
<br>
{{Carnegie stage 16 links}}
<br>
{{Carnegie stage 17 links}}
==Timeline==
{{Week 6 Embryo Stages and Events table}}


==Timeline==
{| class="prettytable"
{| class="prettytable"
|-bgcolor="FAF5FF"
|-bgcolor="FAF5FF"
Line 17: Line 27:
| <center>36</center>
| <center>36</center>
|  
|  
| [[Endocrine_-_Pituitary_Development|Pituitary]] - Week 6 connecting stalk between pouch and oral cavity degenerates  
| {{Pituitary}} - Week 6 connecting stalk between pouch and oral cavity degenerates  


[[Endocrine_-_Parathyroid_Development|Parathyroid]] - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation  
{{Parathyroid}} - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation  


[[Endocrine_-_Thymus_Development|Thymus]] - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation  
{{Thymus}} - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation  


[[Endocrine_-_Adrenal_Development|Adrenal]] - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia  
{{Adrenal}} - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia  


[[Respiratory_System_Development|Respire]] - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes  
{{Respiratory}} - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes  


[http://embryology.med.unsw.edu.au/Notes/tongue.htm Tongue] Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)  
{{Tongue}} Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)  


|-
|-
| <center>37</center>
| <center>37</center>
| [[Carnegie_stage_16|Stage 16]]  
| [[Carnegie_stage_16|Stage 16]]  
| [[File:Stage16_bf1c.jpg|200px|link=Carnegie stage 16]] [[Neural_System_Development|Neural]] - first parasympathetic ganglia, submandibular and ciliary, are identifiable<ref><pubmed>2751117</pubmed></ref>
| [[File:Stage16_bf1c.jpg|200px|link=Carnegie stage 16]] {{Neural}} - first parasympathetic ganglia, submandibular and ciliary, are identifiable{{#pmid:2751117|PMID2751117}}


[http://embryology.med.unsw.edu.au/Notes/skmus7.htm Limbs] upper limb bud '''nerves''' median nerve, radial nerve and ulnar nerve entered into hand plate, '''myoblasts''' spindle shaped and oriented parallel to limb bud axis.
{{Limb}} upper limb bud '''nerves''' median nerve, radial nerve and ulnar nerve entered into hand plate, '''myoblasts''' spindle shaped and oriented parallel to limb bud axis.


[[Cardiovascular_System_Development|Heart]] - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions
{{Heart}} - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions


[http://embryology.med.unsw.edu.au/Notes/head.htm Head] lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.
{{Head}} lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.


|-
|-
Line 60: Line 70:
| [[File:Stage17_bf1c.jpg|200px|link=Carnegie stage 17]]
| [[File:Stage17_bf1c.jpg|200px|link=Carnegie stage 17]]


[[Neural_System_Development|Neural]] - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus<ref><pubmed>2802187</pubmed></ref>
{{Neural}} - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus{{#pmid:2802187|PMID2802187}}


[http://embryology.med.unsw.edu.au/Notes/nose.htm Sense - Smell] olfactory nerve fibres enter the brain<ref><pubmed>15604533</pubmed></ref>  
{{Smell}} olfactory nerve fibres enter the brain<ref><pubmed>15604533</pubmed></ref>  
[[Neural_System_Development|Neural]] - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally<ref><pubmed>15478101</pubmed></ref>
{{Neural}} - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally{{#pmid:15478101|PMID15478101}}


{{Pancreas}} - rotation of the developing stomach moves ventral bud dorsally and fuses with the dorsal bud.
|-
|-
| <center>42</center>
| <center>42</center>
| &nbsp;
| &nbsp;
| [[Cardiovascular_System_Development|Heart]] - separation of common cardiac outflow (aortic arch and pulmonary aorta)
| {{Heart}} - separation of common cardiac outflow (aortic arch and pulmonary aorta)


|}
|}

Latest revision as of 11:32, 16 March 2020

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Key Events of Human Development during the sixth week (week 6) following fertilization or clinical gestational age GA week 8 (LMP).

This week corresponds to Carnegie stages 16 and 17.

Week 6 Links: stage 16 | stage 17 | Lecture - Head | Outflow Tract | Category:Week 6 | GA week 8


Carnegie Stages

Week: 1 2 3 4 5 6 7 8
Carnegie stage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23


Historic Carnegie Stages 16 and 17.

Stage 16 Links: Week 6 | Head | Lecture - Limb | Lecture - Gastrointestinal | Lecture - Head Development | Science Practical - Gastrointestinal | Science Practical - Head | Carnegie Embryos | Category:Carnegie Stage 16 | Week 6 | Next Stage 17
  Historic Papers: 1906 | 1908 | 1948 stages 15-18


Stage 17 Links: Week 6 | System Development | Head | Lecture - Limb | Lecture - Head Development | Lecture - Sensory | Science Practical - Head | Science Practical - Sensory | Science Practical - Urogenital | Carnegie Embryos | Madrid Embryos | Category:Carnegie Stage 17 | Next Stage 18
  Historic Papers: 1926 Precervical Sinus | 1948 stage 15-18

Timeline

Week 6 - Human Embryo Stages and Events (GA week 8) 
Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9
Day
Stage
Event
36
Pituitary - Week 6 connecting stalk between pouch and oral cavity degenerates

Parathyroid - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation

Thymus - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation

Adrenal - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia

Respire - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes

Tongue Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)

37
Stage 16
Stage16 bf1c.jpg
Neural - first parasympathetic ganglia, submandibular and ciliary, are identifiable[1]

Limbs upper limb bud nerves median nerve, radial nerve and ulnar nerve entered into hand plate, myoblasts spindle shaped and oriented parallel to limb bud axis.

Heart - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions

Head lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.

38
   
39
   
40
   
41
Stage 17
Stage17 bf1c.jpg

Neural - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus[2]

Sense - Smell olfactory nerve fibres enter the brain[3] Neural - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally[4]

Pancreas - rotation of the developing stomach moves ventral bud dorsally and fuses with the dorsal bud.

42
  Heart - separation of common cardiac outflow (aortic arch and pulmonary aorta)
Note - the day timing of stages is only approximate, system names link to first page of that specific system, and events are based upon the literature cited below.
References
  1. <pubmed>2751117</pubmed>
  2. <pubmed>2802187</pubmed>
  3. <pubmed>15604533</pubmed>
  4. <pubmed>15478101</pubmed>
Day
Stage
Event
36
pituitary - Week 6 connecting stalk between pouch and oral cavity degenerates

parathyroid - Week 6 diverticulum elongate, hollow then solid, dorsal cell proliferation

thymus - Week 6 diverticulum elongate, hollow then solid, ventral cell proliferation

adrenal - Week 6 fetal cortex forms from mesothelium adjacent to dorsal mesentery, medulla neural crest cells from adjacent sympathetic ganglia

respiratory - Week 6 - descent of heart and lungs into thorax. Pleuroperitoneal foramen closes

tongue Week 6 - gustatory papilla, caudal midline near the foramen caecum (week 6 to 7 - nerve fibers approach the lingual epithelium)

37
Stage 16 Stage16 bf1c.jpg neural - first parasympathetic ganglia, submandibular and ciliary, are identifiable[1]

limb upper limb bud nerves median nerve, radial nerve and ulnar nerve entered into hand plate, myoblasts spindle shaped and oriented parallel to limb bud axis.

heart - outflow tract elliptical configuration with four cushions, the two larger fusing at this stage. Semilunar valve leaflets form at the downstream end of the cushions

head lip and palate components of the upper lip, medial nasal prominence and maxillary process present, median palatine process appears.

38
   
39
   
40
   
41
Stage 17 Stage17 bf1c.jpg

neural - telencephalon areas of the future archicortex, paleocortex, and neocortex, visible. Beginning of future choroid plexus[2]

smell olfactory nerve fibres enter the brain[3] neural - primordium of the epidural space appears first on the ventral part of the vertebral canal and develops rostro-caudally[4]

pancreas - rotation of the developing stomach moves ventral bud dorsally and fuses with the dorsal bud.

42
  heart - separation of common cardiac outflow (aortic arch and pulmonary aorta)

References

  1. Müller F & O'Rahilly R. (1989). The human brain at stage 16, including the initial evagination of the neurohypophysis. Anat. Embryol. , 179, 551-69. PMID: 2751117
  2. Müller F & O'Rahilly R. (1989). The human brain at stage 17, including the appearance of the future olfactory bulb and the first amygdaloid nuclei. Anat. Embryol. , 180, 353-69. PMID: 2802187
  3. <pubmed>15604533</pubmed>
  4. Patelska-Banaszewska M & Woźniak W. (2004). The development of the epidural space in human embryos. Folia Morphol. (Warsz) , 63, 273-9. PMID: 15478101



Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9


Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline


Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link



Cite this page: Hill, M.A. (2024, March 28) Embryology Week 6. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Week_6

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G