Week 3

Introduction

Week 3 embryonic disc

Gastrulation

Key events of human development during the third week (week 3) following fertilization or clinical gestational age week 5, based on last menstrual period.. Note that during this time the conceptus cells not contributing to the embryo are contributing to placental membranes and the early placenta.

During the third week of development conceptus implantion in the uterus wall is complete and trophoblast cells continue to invade uterine wall in the process of early placentation (villi formation). Within the conceptus, gastrulation converts the bilaminar embryo into the trilaminar embryo (ectoderm, mesoderm, endoderm). Morphological changes include an epithelial to mesenchymal cell transition and folding of the embryonic disc. Carnegie stages 7 to 9 covers this period of human embryo development.

Outside of the embryo, the extraembryonic spaces (chorionic, amniotic, yolk) and intraembryonic spaces (coeloms) continue to develop. Trophoblast cells continue to invade uterine wall and the emdometrium is being converted into the decidua, the process of villi formation and early placentation has begun.

Week 3 Links: Gastrulation | Endoderm | Mesoderm | Ectoderm | Placenta | Coelomic Cavity | Lecture | Practical 1-3 | Practical 3-4

Carnegie Stages: 7 | 8 | 9

Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9

Timeline

Day	Stage	Event
15
16	Stage 7	Gastrulation primitive node (Hensen's node, primitive knot) The small circular region located at the cranial end of the primitive streak, where gastrulation occurs, and is a controller of this process. The process establishes the 3 germ cell layers: Endoderm, Mesoderm and Ectoderm. The second role is to act as an initial generator of the left-right (L-R) body axis.
17
18	Stage 8	Neural - neurogenesis, neural groove and folds are first seen
19
20	Stage 9	Musculoskeletal - somitogenesis, first somites form and continue to be added in sequence caudally (1 - 3 somite pairs). Neural - the three main divisions of the brain, which are not cerebral vesicles, can be distinguished while the neural groove is still completely open Neural Crest - mesencephalic neural crest is visible
21		Heart - cardiogenesis, week 3 begins as paired heart tubes.

Week 3 Movies

‎‎Week 3 Mesoderm Page | Play	‎‎Week 3 Notochord Page | Play	‎‎Week 3 Notochord Page | Play	‎‎Nodal Cilia Page | Play
‎‎Week 3 Page | Play	‎‎Amniotic Cavity Page | Play	‎‎Gastrulation ECM Page | Play

Movies

References

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Embryo Week: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9

Carnegie Stages: 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | About Stages | Timeline

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

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Cite this page: Hill, M.A. (2024, April 16) Embryology Week 3. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Week_3

What Links Here?

© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G